In vitro effects of prolactin and hydrocortisone on 7,12 DMBA induced mammary tumour and virus induced sarcoma in the rat

K. Aspegren, Claes G. Tropé

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    Abstract

    The in vitro effect of prolactin and hydrocortisone, singly or in combination, on a DMBA induced mammary tumor in the rat was investigated by organ cultures. Prolactin had a stimulating effect on the DNA synthesis in 1 out of 5 tumors. Hydrocortisone induced lobulo alveolar differentiation but reduced the DNA synthesis or failed to affect it. The addition of prolactin to hydrocortisone did not alter this response. Virus induced rat sarcomas were studied as control tissue. Prolactin inhibited growth of 1 sarcoma. Hydrocortisone stimulated growth of sarcomas. The relevance of these findings in relation to simimalr in vitro experiments is discussed.

    Original languageEnglish (US)
    Pages (from-to)57-62
    Number of pages6
    JournalActa Pathologica et Microbiologica Scandinavica - Section A Pathology
    Volume85
    Issue number1
    StatePublished - Jan 1 1977

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    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Immunology and Allergy
    • Microbiology (medical)

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