In vivo-activation of photodynamic hematoporphyrinderivative (HPD) by HIFU

J. Spoo, J. Jenne, K. Joechle, P. Huber, W. J. Lorenz, M. Wannenmacher, J. Debus

Research output: Contribution to journalConference article

Abstract

Object of our investigations is the in vivo-activation of photosensitizing agents by HIFU in order to minimize side effects and to increase penetration depth of photodynamic treatments. Animal experiments were carried out using the Dunning rat prostrate adenocarcinoma R3327-AT1 in Copenhagen rats. Macroscopic treatment response was evaluated and biologically graded. We were able to assess a synergistic tissue interaction of HIFU (f = 1,18 MHz, I = 3530 W/cm2) and Hematoporphyrin-derivative.

Original languageEnglish (US)
Pages (from-to)1341-1344
Number of pages4
JournalProceedings of the IEEE Ultrasonics Symposium
Volume2
StatePublished - Dec 1 1997
EventProceedings of the 1997 IEEE Ultrasonics Symposium. Part 1 (of 2) - Toronto, Can
Duration: Oct 5 1997Oct 8 1997

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rats
Rats
Chemical activation
activation
animals
Animals
penetration
Tissue
Derivatives
Experiments
interactions

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Spoo, J., Jenne, J., Joechle, K., Huber, P., Lorenz, W. J., Wannenmacher, M., & Debus, J. (1997). In vivo-activation of photodynamic hematoporphyrinderivative (HPD) by HIFU. Proceedings of the IEEE Ultrasonics Symposium, 2, 1341-1344.

In vivo-activation of photodynamic hematoporphyrinderivative (HPD) by HIFU. / Spoo, J.; Jenne, J.; Joechle, K.; Huber, P.; Lorenz, W. J.; Wannenmacher, M.; Debus, J.

In: Proceedings of the IEEE Ultrasonics Symposium, Vol. 2, 01.12.1997, p. 1341-1344.

Research output: Contribution to journalConference article

Spoo, J, Jenne, J, Joechle, K, Huber, P, Lorenz, WJ, Wannenmacher, M & Debus, J 1997, 'In vivo-activation of photodynamic hematoporphyrinderivative (HPD) by HIFU', Proceedings of the IEEE Ultrasonics Symposium, vol. 2, pp. 1341-1344.
Spoo J, Jenne J, Joechle K, Huber P, Lorenz WJ, Wannenmacher M et al. In vivo-activation of photodynamic hematoporphyrinderivative (HPD) by HIFU. Proceedings of the IEEE Ultrasonics Symposium. 1997 Dec 1;2:1341-1344.
Spoo, J. ; Jenne, J. ; Joechle, K. ; Huber, P. ; Lorenz, W. J. ; Wannenmacher, M. ; Debus, J. / In vivo-activation of photodynamic hematoporphyrinderivative (HPD) by HIFU. In: Proceedings of the IEEE Ultrasonics Symposium. 1997 ; Vol. 2. pp. 1341-1344.
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