In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway

Susana Graciela Afonso; Cesar Francisco Polo; Nora Maria Navone; Elba Susana Vazquez; Ana Maria Buzaleh; Ernesto Schoua; del Carmen Batlle Alcira Maria

doi:10.1016/0306-3623(90)90692-F

In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway

Susana Graciela Afonso
, Cesar Francisco Polo
, Nora Maria Navone
, Elba Susana Vazquez
, Ana Maria Buzaleh
, Ernesto Schoua
, del Carmen Batlle Alcira Maria

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

1. The effect of colchicine, vincristin and griseofulvin (GRIS) on the porphyrinogenic action of 2-allyl-2-isopropylacetamide (AIA) and veronal was studied in vivo and using the in vitro experimental model of tissue explant cultures. 2. Complete prevention by colchicine was found in liver and heart explant from animals treated with AIA and veronal. 3. Vincristin, GRIS and colchicine reversed AIA induction in liver explants, however reversal was partial or nil in skin and heart explants depending on the antimitotic and the tissue. 4. The usefulness of the combination of the in vivo experimental model and the in vitro explant tissue culture model, for this kind of studies is emphasized.

Original language	English (US)
Pages (from-to)	423-426
Number of pages	4
Journal	General Pharmacology: The Vascular System
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/0306-3623(90)90692-F
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Pharmacology

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@article{af642e527818403fb80589da0519f75e,

title = "In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway",

abstract = "1. The effect of colchicine, vincristin and griseofulvin (GRIS) on the porphyrinogenic action of 2-allyl-2-isopropylacetamide (AIA) and veronal was studied in vivo and using the in vitro experimental model of tissue explant cultures. 2. Complete prevention by colchicine was found in liver and heart explant from animals treated with AIA and veronal. 3. Vincristin, GRIS and colchicine reversed AIA induction in liver explants, however reversal was partial or nil in skin and heart explants depending on the antimitotic and the tissue. 4. The usefulness of the combination of the in vivo experimental model and the in vitro explant tissue culture model, for this kind of studies is emphasized.",

author = "Afonso, \{Susana Graciela\} and Polo, \{Cesar Francisco\} and Navone, \{Nora Maria\} and Vazquez, \{Elba Susana\} and Buzaleh, \{Ana Maria\} and Ernesto Schoua and \{Alcira Maria\}, \{del Carmen Batlle\}",

note = "Funding Information: Acknowledgemems--A. M. del C. Batlle holds the post of Scientific Researcher in the CONICET; C. Polo, N. M. Navone, S. Afonso, A. M. Buzaleh and E. V\textasciitilde{}zquez are Research Fellows at the CONICET. This work was supported by grants from the CONICET, the SECYT, UBA, Salud Pfiblica, Banco de la Naci6n Argentina.",

year = "1990",

doi = "10.1016/0306-3623(90)90692-F",

language = "English (US)",

volume = "21",

pages = "423--426",

journal = "General Pharmacology: The Vascular System",

issn = "0306-3623",

publisher = "Elsevier BV",

number = "4",

}

TY - JOUR

T1 - In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway

AU - Afonso, Susana Graciela

AU - Polo, Cesar Francisco

AU - Navone, Nora Maria

AU - Vazquez, Elba Susana

AU - Buzaleh, Ana Maria

AU - Schoua, Ernesto

AU - Alcira Maria, del Carmen Batlle

N1 - Funding Information: Acknowledgemems--A. M. del C. Batlle holds the post of Scientific Researcher in the CONICET; C. Polo, N. M. Navone, S. Afonso, A. M. Buzaleh and E. V~zquez are Research Fellows at the CONICET. This work was supported by grants from the CONICET, the SECYT, UBA, Salud Pfiblica, Banco de la Naci6n Argentina.

PY - 1990

Y1 - 1990

N2 - 1. The effect of colchicine, vincristin and griseofulvin (GRIS) on the porphyrinogenic action of 2-allyl-2-isopropylacetamide (AIA) and veronal was studied in vivo and using the in vitro experimental model of tissue explant cultures. 2. Complete prevention by colchicine was found in liver and heart explant from animals treated with AIA and veronal. 3. Vincristin, GRIS and colchicine reversed AIA induction in liver explants, however reversal was partial or nil in skin and heart explants depending on the antimitotic and the tissue. 4. The usefulness of the combination of the in vivo experimental model and the in vitro explant tissue culture model, for this kind of studies is emphasized.

AB - 1. The effect of colchicine, vincristin and griseofulvin (GRIS) on the porphyrinogenic action of 2-allyl-2-isopropylacetamide (AIA) and veronal was studied in vivo and using the in vitro experimental model of tissue explant cultures. 2. Complete prevention by colchicine was found in liver and heart explant from animals treated with AIA and veronal. 3. Vincristin, GRIS and colchicine reversed AIA induction in liver explants, however reversal was partial or nil in skin and heart explants depending on the antimitotic and the tissue. 4. The usefulness of the combination of the in vivo experimental model and the in vitro explant tissue culture model, for this kind of studies is emphasized.

UR - https://www.scopus.com/pages/publications/0025354496

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U2 - 10.1016/0306-3623(90)90692-F

DO - 10.1016/0306-3623(90)90692-F

M3 - Article

C2 - 2379798

AN - SCOPUS:0025354496

SN - 0306-3623

VL - 21

SP - 423

EP - 426

JO - General Pharmacology: The Vascular System

JF - General Pharmacology: The Vascular System

IS - 4

ER -

In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway

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