In vivo verification of particle therapy: How Compton camera configurations affect 3D image quality

D. Mackin, E. Draeger, S. Peterson, J. Polf, S. Beddar

Research output: Contribution to journalConference articlepeer-review

Abstract

The steep dose gradients enabled by the Bragg peaks of particle therapy beams are a double edged sword. They enable highly conformal dose distributions, but even small deviations from the planned beam range can cause overdosing of healthy tissue or under-dosing of the tumour. To reduce this risk, particle therapy treatment plans include margins large enough to account for all the sources of range uncertainty, which include patient setup errors, patient anatomy changes, and CT number to stopping power ratios. Any system that could verify the beam range in vivo, would allow reduced margins and more conformal dose distributions. Toward our goal developing such a system based on Compton camera (CC) imaging, we studied how three configurations (single camera, parallel opposed, and orthogonal) affect the quality of the 3D images. We found that single CC and parallel opposed configurations produced superior images in 2D. The increase in parallax produced by an orthogonal CC configuration was shown to be beneficial in producing artefact free 3D images.

Original languageEnglish (US)
Article number012045
JournalJournal of Physics: Conference Series
Volume847
Issue number1
DOIs
StatePublished - Jun 5 2017
Event9th International Conference on 3D Radiation Dosimetry, IC3DDose 2016 - Galveston, United States
Duration: Nov 7 2016Nov 10 2016

ASJC Scopus subject areas

  • General Physics and Astronomy

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