Incidental detection of oropharyngeal cancer with fluciclovine PET

Amit Jethanandani; Melissa M. Chen; Maria K. Gule-Monroe; William H. Morrison; Stephen Y. Lai; Jason M. Johnson

doi:10.1002/hed.25798

Incidental detection of oropharyngeal cancer with fluciclovine PET

Amit Jethanandani, Melissa M. Chen, Maria K. Gule-Monroe, William H. Morrison, Stephen Y. Lai, Jason M. Johnson

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Fluorine-18-labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid (fluciclovine) is a synthetic amino acid radiopharmaceutical initially developed to improve noninvasive diagnosis of gliomas and currently FDA approved for prostate cancer imaging. Although fluciclovine positron emission tomography (PET) has proven to be efficacious in detecting multiple types of cancer, its ability to detect oropharyngeal squamous cell carcinoma (OPSCC) is largely unknown. Methods: We describe a case of incidental OPSCC detection with fluciclovine PET in a 66-year old male patient during workup for recurrent prostate adenocarcinoma. Results: Fluciclovine PET detected a left base of tongue (BOT) lesion, which was subsequently confirmed as invasive SCC on surgical pathology. Conclusion: Given these findings, we discuss potential future directions for research with fluciclovine to overcome some of the known limitations of ¹⁸[F]fluorodeoxyglucose in oncological imaging.

Original language	English (US)
Pages (from-to)	E141-E145
Journal	Head and Neck
Volume	41
Issue number	8
DOIs	https://doi.org/10.1002/hed.25798
State	Published - Aug 2019

Keywords

CT
FDG
PET
imaging
oropharyngeal carcinoma

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.25798

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title = "Incidental detection of oropharyngeal cancer with fluciclovine PET",

abstract = "Background: Fluorine-18-labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid (fluciclovine) is a synthetic amino acid radiopharmaceutical initially developed to improve noninvasive diagnosis of gliomas and currently FDA approved for prostate cancer imaging. Although fluciclovine positron emission tomography (PET) has proven to be efficacious in detecting multiple types of cancer, its ability to detect oropharyngeal squamous cell carcinoma (OPSCC) is largely unknown. Methods: We describe a case of incidental OPSCC detection with fluciclovine PET in a 66-year old male patient during workup for recurrent prostate adenocarcinoma. Results: Fluciclovine PET detected a left base of tongue (BOT) lesion, which was subsequently confirmed as invasive SCC on surgical pathology. Conclusion: Given these findings, we discuss potential future directions for research with fluciclovine to overcome some of the known limitations of 18[F]fluorodeoxyglucose in oncological imaging.",

keywords = "CT, FDG, PET, imaging, oropharyngeal carcinoma",

author = "Amit Jethanandani and Chen, {Melissa M.} and Gule-Monroe, {Maria K.} and Morrison, {William H.} and Lai, {Stephen Y.} and Johnson, {Jason M.}",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

month = aug,

doi = "10.1002/hed.25798",

language = "English (US)",

volume = "41",

pages = "E141--E145",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "Wiley-Liss Inc.",

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TY - JOUR

T1 - Incidental detection of oropharyngeal cancer with fluciclovine PET

AU - Jethanandani, Amit

AU - Chen, Melissa M.

AU - Gule-Monroe, Maria K.

AU - Morrison, William H.

AU - Lai, Stephen Y.

AU - Johnson, Jason M.

PY - 2019/8

Y1 - 2019/8

N2 - Background: Fluorine-18-labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid (fluciclovine) is a synthetic amino acid radiopharmaceutical initially developed to improve noninvasive diagnosis of gliomas and currently FDA approved for prostate cancer imaging. Although fluciclovine positron emission tomography (PET) has proven to be efficacious in detecting multiple types of cancer, its ability to detect oropharyngeal squamous cell carcinoma (OPSCC) is largely unknown. Methods: We describe a case of incidental OPSCC detection with fluciclovine PET in a 66-year old male patient during workup for recurrent prostate adenocarcinoma. Results: Fluciclovine PET detected a left base of tongue (BOT) lesion, which was subsequently confirmed as invasive SCC on surgical pathology. Conclusion: Given these findings, we discuss potential future directions for research with fluciclovine to overcome some of the known limitations of 18[F]fluorodeoxyglucose in oncological imaging.

AB - Background: Fluorine-18-labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid (fluciclovine) is a synthetic amino acid radiopharmaceutical initially developed to improve noninvasive diagnosis of gliomas and currently FDA approved for prostate cancer imaging. Although fluciclovine positron emission tomography (PET) has proven to be efficacious in detecting multiple types of cancer, its ability to detect oropharyngeal squamous cell carcinoma (OPSCC) is largely unknown. Methods: We describe a case of incidental OPSCC detection with fluciclovine PET in a 66-year old male patient during workup for recurrent prostate adenocarcinoma. Results: Fluciclovine PET detected a left base of tongue (BOT) lesion, which was subsequently confirmed as invasive SCC on surgical pathology. Conclusion: Given these findings, we discuss potential future directions for research with fluciclovine to overcome some of the known limitations of 18[F]fluorodeoxyglucose in oncological imaging.

KW - CT

KW - FDG

KW - PET

KW - imaging

KW - oropharyngeal carcinoma

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JO - Head and Neck

JF - Head and Neck

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ER -

Incidental detection of oropharyngeal cancer with fluciclovine PET

Abstract

Keywords

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