Incidentally discovered myelolipomatous adrenal adenomas, including six cases presenting with hypercortisolism

Katrina Collins, Diana M. Oramas, Jeffrey Guccione, Khaled M. Elsayes, Mouhammed A. Habra, Miao Zhang, Liang Cheng

Research output: Contribution to journalArticlepeer-review

Abstract

Most adrenal incidentalomas are non-functioning adenomas that require no treatment. The presence of a myelolipomatous component of adrenal incidentalomas is a rare, but well-known occurrence in both hyperplastic and neoplastic lesions of the adrenal cortex. Although the improvements in abdominal imaging have increased identification of myelolipomatous adrenal cortical adenomas radiologically, due to the rarity of this lesion, the clinical pathological features of these lesions are unclear and can sometimes cause diagnostic difficulty. Eleven patients had surgeries at The University of Texas MD Anderson Cancer Center. Four additional cases were provided from an external collaborator. Of the 15 cases, there were 5 male and 10 female patients, with a median age of 52 years (mean 54 years, range 28–84 years). Clinical presentation included adrenal incidentaloma (n = 9), Cushing syndrome (n = 4, including 1 as a part of Carney complex), and subclinical Cushing syndrome (n = 2, including 1 with bilateral macronodular adrenal hyperplasia). In this study, we present the clinicopathologic features of fifteen myelolipomatous adrenal adenomas, the largest series published thus far.

Original languageEnglish (US)
Article number153508
JournalPathology Research and Practice
Volume224
DOIs
StatePublished - Aug 2021

Keywords

  • Adrenal gland
  • Adrenalectomy
  • Cushing syndrome
  • Hypercortisolism
  • Myelolipoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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