TY - JOUR
T1 - Incorporating prognostic information into treatment decisions in chronic lymphocytic leukemia
AU - Jain, Nitin
AU - Lamanna, Nicole
PY - 2009
Y1 - 2009
N2 - Most patients with chronic lymphocytic leukemia are diagnosed at an early stage, when traditional staging systems fail to distinguish those with an aggressive disease course from those with an excellent prognosis. This failure underscores the need for better prognostic markers. Although many markers have been explored, this review focuses on the newer and most clinically relevant markers: cytogenetic aberrations, zeta-associated protein 70, immunoglobulin mutational status, and CD38 expression. Although these markers have been shown to predict outcomes for groups of patients, individual patients may have a variable course; therefore, the outcome for any one patient remains hard to predict. To date, no study has shown a benefit from early cytotoxic therapy for any subgroup of patients with chronic lymphocytic leukemia.
AB - Most patients with chronic lymphocytic leukemia are diagnosed at an early stage, when traditional staging systems fail to distinguish those with an aggressive disease course from those with an excellent prognosis. This failure underscores the need for better prognostic markers. Although many markers have been explored, this review focuses on the newer and most clinically relevant markers: cytogenetic aberrations, zeta-associated protein 70, immunoglobulin mutational status, and CD38 expression. Although these markers have been shown to predict outcomes for groups of patients, individual patients may have a variable course; therefore, the outcome for any one patient remains hard to predict. To date, no study has shown a benefit from early cytotoxic therapy for any subgroup of patients with chronic lymphocytic leukemia.
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U2 - 10.1007/s11912-009-0048-9
DO - 10.1007/s11912-009-0048-9
M3 - Review article
C2 - 19679010
AN - SCOPUS:68949100532
SN - 1523-3790
VL - 11
SP - 353
EP - 359
JO - Current oncology reports
JF - Current oncology reports
IS - 5
ER -