TY - CHAP
T1 - Increased adiposity and endometrial cancer risk
AU - Lu, Karen H.
AU - Klopp, Ann H.
AU - Soliman, Pamela T.
AU - Schmandt, Rosemarie E.
N1 - Publisher Copyright:
© 2013 Springer Science+Business Media New York. All rights are reserved.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2013/4/1
Y1 - 2013/4/1
N2 - Among all cancers, increasing body mass index is most strongly associated with endometrial cancer incidence and mortality. The molecular mechanisms underlying the role of obesity, and in particular the role of visceral fat, to the pathogenesis of endometrial cancer are becoming better understood. The current body of knowledge suggests several rational strategies, including behavioral, pharmaceutical, and surgical interventions, can be used to circumvent or derail the aberrant signaling pathways and hormonal abnormalities associated with obesity. Given the growing worldwide obesity epidemic, the development and availability of therapeutics, which can reduce the impact of obesity on endometrial cancer risk is imperative.
AB - Among all cancers, increasing body mass index is most strongly associated with endometrial cancer incidence and mortality. The molecular mechanisms underlying the role of obesity, and in particular the role of visceral fat, to the pathogenesis of endometrial cancer are becoming better understood. The current body of knowledge suggests several rational strategies, including behavioral, pharmaceutical, and surgical interventions, can be used to circumvent or derail the aberrant signaling pathways and hormonal abnormalities associated with obesity. Given the growing worldwide obesity epidemic, the development and availability of therapeutics, which can reduce the impact of obesity on endometrial cancer risk is imperative.
UR - http://www.scopus.com/inward/record.url?scp=84929542116&partnerID=8YFLogxK
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U2 - 10.1007/978-1-4614-7660-3_4
DO - 10.1007/978-1-4614-7660-3_4
M3 - Chapter
AN - SCOPUS:84929542116
SN - 1461476593
SN - 9781461476597
SP - 53
EP - 69
BT - Adipose tissue and cancer
PB - Springer New York
ER -