Abstract
We describe an unusual case of indolent peripheral T-cell lymphoma with multifocal involvement of the gastrointestinal tract. The patient, a 42-year-old Asian man, has been followed up for more than 10 years without chemotherapy and multiple gastrointestinal biopsies showing similar findings. Histologically, the neoplasm expanded into the lamina propria and/or focally extended into the submucosa and was composed of small- to medium-sized lymphocytes with slightly irregular nuclear contours and clear cytoplasm and rare large lymphocytes. The tumor cells were positive for CD3, CD8, granzyme B, and TIA-1 (subset) and negative for CD5, CD56, and Epstein-Barr virus-encoded RNA. Molecular studies for T-cell receptor γ and/or β chain gene rearrangement demonstrated the same clone at different sites and times during the course of the disease. Rare cases of indolent peripheral T-cell lymphoma of the gastrointestinal tract have been previously described and need to be further characterized to avoid the use of aggressive chemotherapy.
Original language | English (US) |
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Pages (from-to) | 421-426 |
Number of pages | 6 |
Journal | Human Pathology |
Volume | 45 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2014 |
Keywords
- Gastrointestinal tract
- Indolent lymphoma
- NK-cell enteropathy
- T-cell lymphoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
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