@article{59573e80ec58455cbc7bfe8ded8bc33a,
title = "Induction of antitumor immunity in mice by the combination of nanoparticle-based photothermolysis and anti-PD-1 checkpoint inhibition",
abstract = "Generation of durable tumor-specific immune response without isolation and expansion of dendritic cells or T cells ex vivo remains a challenge. In this study, we investigated the impact of nanoparticle-mediated photothermolysis in combination with checkpoint inhibition on the induction of systemic antitumor immunity. Photothermolysis based on near-infrared light-absorbing copper sulfide nanoparticles and 15-ns laser pulses combined with the immune checkpoint inhibitor anti-PD-1 antibody (αPD-1) increased tumor infiltration by antigen-presenting cells and CD8-positive T lymphocytes in the B16-OVA mouse model. Moreover, combined photothermolysis, polymeric conjugate of the Toll-like receptor 9 agonist CpG, and αPD-1 significantly prolonged mouse survival after re-inoculation of tumor cells at a distant site compared to individual treatments alone in the poorly immunogenic syngeneic ID8-ip1-Luc ovarian tumor model. Thus, photothermolysis is a promising interventional technique that synergizes with Toll-like receptor 9 agonists and immune checkpoint inhibitors to enhance the abscopal effect in tumors.",
keywords = "Abscopal effect, Checkpoint inhibitor, CuS nanoparticle, Photothermolysis, Pulsed laser",
author = "Qizhen Cao and Wanqin Wang and Min Zhou and Qian Huang and Xiaoxia Wen and Jun Zhao and Sixiang Shi and Ku Geng and Fenge Li and Hiroto Hatakeyama and Chunyu Xu and David Piwnica-Worms and Weiyi Peng and Dapeng Zhou and Sood, {Anil K.} and Chun Li",
note = "Funding Information: Financial support: We acknowledge that this work was supported in part by the John S. Dunn, Sr., Distinguished Chair in Diagnostic Imaging (Dr. William A. Murphy, Jr.) and by the University Cancer Foundation via the Institutional Research Grant program at The University of Texas MD Anderson Cancer Center. Additionally, A.K.S. was supported by grants P50 CA217685 and R35 CA209904 from the National Cancer Institute; the American Cancer Society Research Professor Award; and the Frank McGraw Memorial Chair in Cancer Research. We acknowledge support by the NIH/NCI under award number P30CA016672 for the use of the High-Resolution Electron Microscopy, Flow Cytometry and Cellular Imaging, and Small Animal Imaging core facilities.The authors thank Ms. Stephanie P. Deming of Scientific Publications, Research Medical Library, MD Anderson Cancer Center, for editing the manuscript. We acknowledge that this work was supported in part by the John S. Dunn, Sr. Distinguished Chair in Diagnostic Imaging (Dr. William A. Murphy, Jr.) and by the University Cancer Foundation via the Institutional Research Grant program at The University of Texas MD Anderson Cancer Center. Additionally, A.K.S. was supported by grants P50 CA217685 and R35 CA209904 from the National Cancer Institute; the American Cancer Society Research Professor Award; and the Frank McGraw Memorial Chair in Cancer Research. We acknowledge support by the NIH/NCI under award number P30CA016672 for the use of the High-Resolution Electron Microscopy, Flow Cytometry & Cellular Imaging, and Small Animal Imaging core facilities. Funding Information: The authors thank Ms. Stephanie P. Deming of Scientific Publications, Research Medical Library, MD Anderson Cancer Center, for editing the manuscript. We acknowledge that this work was supported in part by the John S. Dunn, Sr., Distinguished Chair in Diagnostic Imaging (Dr. William A. Murphy, Jr.) and by the University Cancer Foundation via the Institutional Research Grant program at The University of Texas MD Anderson Cancer Center. Additionally, A.K.S. was supported by grants P50 CA217685 and R35 CA209904 from the National Cancer Institute ; the American Cancer Society Research Professor Award ; and the Frank McGraw Memorial Chair in Cancer Research . We acknowledge support by the NIH/NCI under award number P30CA016672 for the use of the High-Resolution Electron Microscopy, Flow Cytometry & Cellular Imaging, and Small Animal Imaging core facilities. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = apr,
doi = "10.1016/j.nano.2020.102169",
language = "English (US)",
volume = "25",
journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",
issn = "1549-9634",
publisher = "Elsevier Inc.",
}