TY - JOUR
T1 - Infections with the agent of ‘kennel cough’ in patients with cancer
AU - Szvalb, Ariel D.
AU - Rolston, Kenneth V.
AU - Mori, Nobuyoshi
AU - Tarrand, Jeffrey J.
AU - Mulanovich, Victor E.
N1 - Funding Information:
This study was supported in part by funds from The University of Texas MD Anderson Cancer Center , Houston, Texas, and by the National Institutes of Health/National Cancer Institute, under award number P30CA016672.
Publisher Copyright:
© 2018
PY - 2019/1
Y1 - 2019/1
N2 - Objective: To investigate the clinical manifestations, microbiological data, and outcomes of Bordetella bronchiseptica (Bb) infections in patients with cancer. Methods: Review of electronic medical records of 24 patients with Bb infection, from 2000 to 2013. An infection was considered to be associated with Bb if both clinical manifestations plus microbial growth from infected sites were present. Results: Ten patients (42%) had a monomicrobial infection, whereas multiple pathogens in addition to Bb were isolated from the rest (14 patients, 58%). The most frequent sites of infection were the respiratory tract (18 patients, 75 %) and bloodstream (17%). The most frequently associated conditions were lymphopenia (71%), tobacco use (42%), and chemotherapeutic or immunosuppressive agents (33% each). Animal exposure was established in four patients. Overall, the response rate to treatment was 100% for monomicrobial and 79% for polymicrobial infections, respectively. Conclusions: Bb is an uncommon pathogen even in immunosuppressed patients. Predominant sites of infection are the respiratory tract and bloodstream. Bb should be considered pathogenic in immunocompromised hosts, particularly with history of zoonotic exposure, even if accompanied by co-pathogens. Therefore, contact with potential animal sources should be minimized. The infection ranges from mild to severe and has no specific clinical or radiographic manifestations.
AB - Objective: To investigate the clinical manifestations, microbiological data, and outcomes of Bordetella bronchiseptica (Bb) infections in patients with cancer. Methods: Review of electronic medical records of 24 patients with Bb infection, from 2000 to 2013. An infection was considered to be associated with Bb if both clinical manifestations plus microbial growth from infected sites were present. Results: Ten patients (42%) had a monomicrobial infection, whereas multiple pathogens in addition to Bb were isolated from the rest (14 patients, 58%). The most frequent sites of infection were the respiratory tract (18 patients, 75 %) and bloodstream (17%). The most frequently associated conditions were lymphopenia (71%), tobacco use (42%), and chemotherapeutic or immunosuppressive agents (33% each). Animal exposure was established in four patients. Overall, the response rate to treatment was 100% for monomicrobial and 79% for polymicrobial infections, respectively. Conclusions: Bb is an uncommon pathogen even in immunosuppressed patients. Predominant sites of infection are the respiratory tract and bloodstream. Bb should be considered pathogenic in immunocompromised hosts, particularly with history of zoonotic exposure, even if accompanied by co-pathogens. Therefore, contact with potential animal sources should be minimized. The infection ranges from mild to severe and has no specific clinical or radiographic manifestations.
KW - Bordetella bronchiseptica
KW - Kennel cough in humans
KW - Respiratory tract infection
KW - Zoonosis
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U2 - 10.1016/j.jinf.2018.07.010
DO - 10.1016/j.jinf.2018.07.010
M3 - Article
C2 - 30048653
AN - SCOPUS:85050855551
SN - 0163-4453
VL - 78
SP - 48
EP - 53
JO - Journal of Infection
JF - Journal of Infection
IS - 1
ER -