Inflammatory cytokines and peripheral mediators in the pathophysiology of pruritus in cutaneous T-cell lymphoma

D. J. Lewis, S. Huang, M. Duvic

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Cutaneous T-cell lymphoma (CTCL) includes a diverse group of neoplasms, including mycosis fungoides and Sézary syndrome. One of the earliest and most common symptoms of CTCL is pruritus, which affects up to 88% of patients. The severity of pruritus can range from mild to very debilitating, producing tremendous discomfort and a significant decrease in quality of life. Patients with advanced disease, in particular, may experience a more chronic, intractable pruritus. However, the underlying mechanism of pruritus in CTCL remains unknown. Conventional antipruritic agents, such as antihistamines, gamma-aminobutyric acid analogs and antidepressants, are only partially effective in relieving symptoms, suggesting a more complex, unique pathophysiology. In this review, we summarize the current research on cytokines and peripheral mediators implicated in pruritus in CTCL.

Original languageEnglish (US)
Pages (from-to)1652-1656
Number of pages5
JournalJournal of the European Academy of Dermatology and Venereology
Volume32
Issue number10
DOIs
StatePublished - Oct 2018

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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