Influence of risk grouping on therapeutic decisions in patients with anaplastic thyroid carcinoma

Chuanzheng Sun, Chao Li, Zedong Hu, Xiaojiang Li, Jiehua He, Ming Song, Guojun Li, Fenghua Zhang, Qiuli Li

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We investigated prognostic factors in 42 anaplastic thyroid carcinoma (ATC) patients from a single institution over a 30-year period and explored the use of risk grouping to guide therapeutic decisions. Univariable and multivariable differences in overall survival (OS) were evaluated using the Kaplan–Meier method and the log-rank test as well as Cox proportional hazards model. Risk grouping in making therapeutic decisions for ATC patients was explored. The 1- and 3-year OS rates were 28.6 % and 18.5 %, respectively. Univariate analysis indicated that 4 pre-therapeutic factors of patients were related to poorer prognoses: age ≥ 55 years, white blood cell count ≥ 10.0 × 109/L, blood platelet count ≥ 300.0 × 109/L and advanced clinical tumor-node-metastasis stage. These factors were used to calculate the risk indices. Patients with total risk index scores of no more than 1 were considered to be in the low-risk group, and patients with scores ≥ 2 were considered to be in the high-risk group. The patients in the low-risk group had significantly better 1- and 3-year OS rates (90.9 % and 63.6 %, respectively) than those in the high-risk group (6.5 % and 3.2 %, respectively). Risk group and therapeutic regimen were the 2 factors that independently influenced survival according to multivariable analysis. Surgery that was combined with postoperative radiotherapy significantly benefited the patients in the low-risk group rather than the patients in the high-risk group. Risk grouping was a helpful tool of evaluating the prognoses and guiding the treatment of ATC patients.

Original languageEnglish (US)
Pages (from-to)985-993
Number of pages9
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume272
Issue number4
DOIs
StatePublished - Jan 1 2015

Fingerprint

Therapeutics
Anaplastic Thyroid Carcinoma
Survival Rate
Survival
Proportional Hazards Models
Decision Making
Leukocytes
Radiotherapy
Blood Platelets
Neoplasm Metastasis
Neoplasms

Keywords

  • Anaplastic thyroid carcinoma
  • Blood platelet count
  • Risk grouping
  • Therapeutic decisions
  • White blood cell count

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Influence of risk grouping on therapeutic decisions in patients with anaplastic thyroid carcinoma. / Sun, Chuanzheng; Li, Chao; Hu, Zedong; Li, Xiaojiang; He, Jiehua; Song, Ming; Li, Guojun; Zhang, Fenghua; Li, Qiuli.

In: European Archives of Oto-Rhino-Laryngology, Vol. 272, No. 4, 01.01.2015, p. 985-993.

Research output: Contribution to journalArticle

Sun, Chuanzheng ; Li, Chao ; Hu, Zedong ; Li, Xiaojiang ; He, Jiehua ; Song, Ming ; Li, Guojun ; Zhang, Fenghua ; Li, Qiuli. / Influence of risk grouping on therapeutic decisions in patients with anaplastic thyroid carcinoma. In: European Archives of Oto-Rhino-Laryngology. 2015 ; Vol. 272, No. 4. pp. 985-993.
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