Inhibition of pleural metastasis of collecting duct carcinoma of the kidney by modified cytokine-induced killer cells: A case report and review of the literature

Jingyi Liu, Jun Sui, Zhiwei Zhang, Xiubao Ren, Li Luan, Qisheng Yang, Songhai Gu, Rudolf Wank, Barbara Laumbacher, Xin Song

    Research output: Contribution to journalArticle

    1 Scopus citations


    Collecting duct carcinoma (CDC) or Bellini duct carcinoma of the kidney is a rare, but highly aggressive renal epithelial malignancy, with an extremely poor prognosis. Modified cytokine-induced killer (mCIK) cells were injected into the pleural cavity to treat pleural metastasis of CDC. The patient, a 33-year-old male, was admitted to hospital for further treatment for severe pleural metastasis of CDC. We cured the pleural metastasis through intrapleural infusion with mCIK cells. After receiving this innovative treatment, the patient exhibited a positive response: the cough, dyspnea, chest distress and thoracalgia were evidently relieved, while the pleural fluid became clear after exhibiting haematodes and its level decreased significantly. The patient achieved partial success. This novel immunotherapy method is a promising treatment for patients with refractory pleural metastasis.

    Original languageEnglish (US)
    Pages (from-to)955-958
    Number of pages4
    JournalOncology Letters
    Issue number6
    StatePublished - Nov 1 2010



    • Collecting duct carcinoma
    • Immunotherapy
    • Pleural metastasis

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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