Abstract
Purpose of reviewPoly(ADP-ribose) polymerase (PARP) inhibitors were recently approved for the treatment of patients with BRCA1 or BRCA2 germline pathogenic variants and metastatic breast cancer. PARP inhibitors have also demonstrated activity in early stage breast cancer, and this review discusses completed and ongoing trials of PARP inhibitors in the neoadjuvant and adjuvant setting.Recent findingsA recent phase II trial of neoadjuvant talazoparib monotherapy in patients with BRCA1 or BRCA2 germline pathogenic variants and early stage breast cancer demonstrated a pathological complete response in 10/19 (53%) patients. Previous trials of PARP inhibition in early stage breast cancer included the I-SPY-2 and BrighTNess trials, which ultimately failed to show a benefit for adding the PARP inhibitor veliparib to standard neoadjuvant chemotherapy in patients with triple-negative breast cancer. Investigators are building on these results by designing novel clinical trials for patients with BRCA1/2-deficient tumors and/or triple-negative breast cancer.SummaryThe OlympiAD and EMBRACA trials that led to the recent approval of PARP inhibitors for metastatic breast cancer patients with BRCA1/2 germline pathogenic variants are practice changing. Investigators are now working to translate this success into the early breast cancer setting where ongoing trials incorporate new dosing schedules, PARP inhibitor monotherapy, and novel PARP combinations.
Original language | English (US) |
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Pages (from-to) | 247-255 |
Number of pages | 9 |
Journal | Current opinion in oncology |
Volume | 31 |
Issue number | 3 |
DOIs | |
State | Published - May 1 2019 |
Keywords
- BRCA1/2 deficiency
- early stage breast cancer
- neoadjuvant therapy
- poly(ADP-ribose) polymerase inhibitors
- triple-negative breast cancer
ASJC Scopus subject areas
- Oncology
- Cancer Research