Integration of Whole-Genome Sequencing With Circulating Tumor DNA Analysis Captures Clonal Evolution and Tumor Heterogeneity in Non-V600 BRAF Mutant Colorectal Cancer

Shehara Mendis; Miguel Alcaide; James T. Topham; Benny Johnson; Ryan D. Morin; Jenny Chu; Ian Bosdet; Scott Kopetz; Aly Karsan; Sharlene Gill; Janessa Laskin; Steven J.M. Jones; Marco A. Marra; David F. Schaeffer; Daniel J. Renouf; Jonathan Michael Loree

doi:10.1016/j.clcc.2020.02.001

Integration of Whole-Genome Sequencing With Circulating Tumor DNA Analysis Captures Clonal Evolution and Tumor Heterogeneity in Non-V600 BRAF Mutant Colorectal Cancer

Shehara Mendis, Miguel Alcaide, James T. Topham, Benny Johnson, Ryan D. Morin, Jenny Chu, Ian Bosdet, Scott Kopetz, Aly Karsan, Sharlene Gill, Janessa Laskin, Steven J.M. Jones, Marco A. Marra, David F. Schaeffer, Daniel J. Renouf, Jonathan Michael Loree

GI Medical Oncology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Original language	English (US)
Pages (from-to)	132-136.e3
Journal	Clinical colorectal cancer
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/j.clcc.2020.02.001
State	Published - Jun 2020

Keywords

Anti-epidermal growth factor receptor
Colon
Colorectal neoplasms
EGFR
ctDNA

ASJC Scopus subject areas

Oncology
Gastroenterology

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10.1016/j.clcc.2020.02.001

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Mendis, S., Alcaide, M., Topham, J. T., Johnson, B., Morin, R. D., Chu, J., Bosdet, I., Kopetz, S., Karsan, A., Gill, S., Laskin, J., Jones, S. J. M., Marra, M. A., Schaeffer, D. F., Renouf, D. J., & Loree, J. M. (2020). Integration of Whole-Genome Sequencing With Circulating Tumor DNA Analysis Captures Clonal Evolution and Tumor Heterogeneity in Non-V600 BRAF Mutant Colorectal Cancer. Clinical colorectal cancer, 19(2), 132-136.e3. https://doi.org/10.1016/j.clcc.2020.02.001

Mendis, S, Alcaide, M, Topham, JT, Johnson, B, Morin, RD, Chu, J, Bosdet, I, Kopetz, S, Karsan, A, Gill, S, Laskin, J, Jones, SJM, Marra, MA, Schaeffer, DF, Renouf, DJ & Loree, JM 2020, 'Integration of Whole-Genome Sequencing With Circulating Tumor DNA Analysis Captures Clonal Evolution and Tumor Heterogeneity in Non-V600 BRAF Mutant Colorectal Cancer', Clinical colorectal cancer, vol. 19, no. 2, pp. 132-136.e3. https://doi.org/10.1016/j.clcc.2020.02.001

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title = "Integration of Whole-Genome Sequencing With Circulating Tumor DNA Analysis Captures Clonal Evolution and Tumor Heterogeneity in Non-V600 BRAF Mutant Colorectal Cancer",

keywords = "Anti-epidermal growth factor receptor, Colon, Colorectal neoplasms, EGFR, ctDNA",

author = "Shehara Mendis and Miguel Alcaide and Topham, {James T.} and Benny Johnson and Morin, {Ryan D.} and Jenny Chu and Ian Bosdet and Scott Kopetz and Aly Karsan and Sharlene Gill and Janessa Laskin and Jones, {Steven J.M.} and Marra, {Marco A.} and Schaeffer, {David F.} and Renouf, {Daniel J.} and Loree, {Jonathan Michael}",

note = "Funding Information: We gratefully acknowledge the participation of our patients and families, the Personalized Onco-Genomics team, and the generous support of the BC Cancer Foundation and Genome British Columbia (project B20POG). We also acknowledge contributions toward equipment and infrastructure from Genome Canada and Genome BC (projects 202SEQ, 212SEQ, 12002), Canada Foundation for Innovation (projects 20070, 30198, 30981, 33408), and the BC Knowledge Development Fund. The results published herein are in part on the basis of data generated by the following projects and obtained from dbGaP (http://www.ncbi.nlm.nih.gov/gap): the Cancer Genome Atlas managed by the National Cancer Institute and National Human Genome Research Institute (http://cancergenome.nih.gov); Genotype-Tissue Expression Project, supported by the Common Fund of the Office of the Director of the National Institutes of Health (https://commonfund.nih.gov/GTEx). Funding Information: We gratefully acknowledge the participation of our patients and families, the Personalized Onco-Genomics team, and the generous support of the BC Cancer Foundation and Genome British Columbia (project B20POG). We also acknowledge contributions toward equipment and infrastructure from Genome Canada and Genome BC (projects 202SEQ, 212SEQ, 12002), Canada Foundation for Innovation (projects 20070, 30198, 30981, 33408), and the BC Knowledge Development Fund . The results published herein are in part on the basis of data generated by the following projects and obtained from dbGaP ( http://www.ncbi.nlm.nih.gov/gap ): the Cancer Genome Atlas managed by the National Cancer Institute and National Human Genome Research Institute ( http://cancergenome.nih.gov ); Genotype-Tissue Expression Project, supported by the Common Fund of the Office of the Director of the National Institutes of Health ( https://commonfund.nih.gov/GTEx ). ",

year = "2020",

month = jun,

doi = "10.1016/j.clcc.2020.02.001",

language = "English (US)",

volume = "19",

pages = "132--136.e3",

journal = "Clinical colorectal cancer",

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T1 - Integration of Whole-Genome Sequencing With Circulating Tumor DNA Analysis Captures Clonal Evolution and Tumor Heterogeneity in Non-V600 BRAF Mutant Colorectal Cancer

AU - Mendis, Shehara

AU - Alcaide, Miguel

AU - Topham, James T.

AU - Johnson, Benny

AU - Morin, Ryan D.

AU - Chu, Jenny

AU - Bosdet, Ian

AU - Kopetz, Scott

AU - Karsan, Aly

AU - Gill, Sharlene

AU - Laskin, Janessa

AU - Jones, Steven J.M.

AU - Marra, Marco A.

AU - Schaeffer, David F.

AU - Renouf, Daniel J.

AU - Loree, Jonathan Michael

N1 - Funding Information: We gratefully acknowledge the participation of our patients and families, the Personalized Onco-Genomics team, and the generous support of the BC Cancer Foundation and Genome British Columbia (project B20POG). We also acknowledge contributions toward equipment and infrastructure from Genome Canada and Genome BC (projects 202SEQ, 212SEQ, 12002), Canada Foundation for Innovation (projects 20070, 30198, 30981, 33408), and the BC Knowledge Development Fund. The results published herein are in part on the basis of data generated by the following projects and obtained from dbGaP (http://www.ncbi.nlm.nih.gov/gap): the Cancer Genome Atlas managed by the National Cancer Institute and National Human Genome Research Institute (http://cancergenome.nih.gov); Genotype-Tissue Expression Project, supported by the Common Fund of the Office of the Director of the National Institutes of Health (https://commonfund.nih.gov/GTEx). Funding Information: We gratefully acknowledge the participation of our patients and families, the Personalized Onco-Genomics team, and the generous support of the BC Cancer Foundation and Genome British Columbia (project B20POG). We also acknowledge contributions toward equipment and infrastructure from Genome Canada and Genome BC (projects 202SEQ, 212SEQ, 12002), Canada Foundation for Innovation (projects 20070, 30198, 30981, 33408), and the BC Knowledge Development Fund . The results published herein are in part on the basis of data generated by the following projects and obtained from dbGaP ( http://www.ncbi.nlm.nih.gov/gap ): the Cancer Genome Atlas managed by the National Cancer Institute and National Human Genome Research Institute ( http://cancergenome.nih.gov ); Genotype-Tissue Expression Project, supported by the Common Fund of the Office of the Director of the National Institutes of Health ( https://commonfund.nih.gov/GTEx ).

PY - 2020/6

Y1 - 2020/6

KW - Anti-epidermal growth factor receptor

KW - Colon

KW - Colorectal neoplasms

KW - EGFR

KW - ctDNA

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Integration of Whole-Genome Sequencing With Circulating Tumor DNA Analysis Captures Clonal Evolution and Tumor Heterogeneity in Non-V600 BRAF Mutant Colorectal Cancer

Keywords

ASJC Scopus subject areas

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