Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E

Seon Hee Chang, Joseph M. Reynolds, Bhanu P. Pappu, Guangjie Chen, Gustavo J. Martinez, Chen Dong

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Although several interleukin-17 (IL-17) family members and their receptors have been recently appreciated as important regulators in inflammatory diseases, the function of other IL-17 cytokines and IL-17 receptor-like molecules is unclear. Here we show that an IL-17 cytokine family member, IL-17C, was induced in a Th17 cell-dependent autoimmune disease and was required for its pathogenesis. IL-17C bound to IL-17RE, a member of IL-17 receptor family whose full-length isoform was selectively expressed in Th17 cells and signaled via an IL-17RA-RE receptor complex and the downstream adaptor Act1. IL-17C-IL-17RE induced the expression of a nuclear IkappaB family member, IκBζ, in Th17 cells to potentiate the Th17 cell response. Thus, our work has identified a cytokine-receptor pair with important function in regulating proinflammatory responses. This pathway may be targeted to treat autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)611-621
Number of pages11
JournalImmunity
Volume35
Issue number4
DOIs
StatePublished - Oct 28 2011

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Interleukin-17 Receptors
Th17 Cells
Interleukin-17
Autoimmune Diseases
Cytokines
Cytokine Receptors
Nuclear Family
Protein Isoforms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E. / Chang, Seon Hee; Reynolds, Joseph M.; Pappu, Bhanu P.; Chen, Guangjie; Martinez, Gustavo J.; Dong, Chen.

In: Immunity, Vol. 35, No. 4, 28.10.2011, p. 611-621.

Research output: Contribution to journalArticle

Chang, Seon Hee ; Reynolds, Joseph M. ; Pappu, Bhanu P. ; Chen, Guangjie ; Martinez, Gustavo J. ; Dong, Chen. / Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E. In: Immunity. 2011 ; Vol. 35, No. 4. pp. 611-621.
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