Interleukin-8 derived from local tissue-resident stromal cells promotes tumor cell invasion

Gabriel Welte, Eckhard Alt, Eswaran Devarajan, Srinivasalu Krishnappa, Constantin Jotzu, Yao Hua Song

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The aim of this study is to evaluate the role of adipose tissue resident stromal cells on tumor cell invasion. Our data show that a subpopulation of adipose tissue derived stromal cells expressing Nestin, NG2, α-smooth muscle actin and PDGFR-α migrate toward the cancer cells. Microarray analysis revealed the upregulation of IL-8 in the migrated cells. We demonstrated that stromal cell derived IL-8 promote the invasion and the anchorage-independent growth of cancer cells. We conclude that human breast cancer cells attract a subpopulation of stromal cells that secrete IL-8 to promote tumor cell invasion in a paracrine fashion.

Original languageEnglish (US)
Pages (from-to)861-868
Number of pages8
JournalMolecular Carcinogenesis
Volume51
Issue number11
DOIs
StatePublished - Nov 2012

Keywords

  • Breast cancer
  • IL-8
  • Microarray
  • Stem cell
  • Stromal cell
  • Tumor invasion

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

MD Anderson CCSG core facilities

  • Flow Cytometry and Cellular Imaging Facility

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