Abstract
The aim of this study is to evaluate the role of adipose tissue resident stromal cells on tumor cell invasion. Our data show that a subpopulation of adipose tissue derived stromal cells expressing Nestin, NG2, α-smooth muscle actin and PDGFR-α migrate toward the cancer cells. Microarray analysis revealed the upregulation of IL-8 in the migrated cells. We demonstrated that stromal cell derived IL-8 promote the invasion and the anchorage-independent growth of cancer cells. We conclude that human breast cancer cells attract a subpopulation of stromal cells that secrete IL-8 to promote tumor cell invasion in a paracrine fashion.
Original language | English (US) |
---|---|
Pages (from-to) | 861-868 |
Number of pages | 8 |
Journal | Molecular Carcinogenesis |
Volume | 51 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2012 |
Keywords
- Breast cancer
- IL-8
- Microarray
- Stem cell
- Stromal cell
- Tumor invasion
ASJC Scopus subject areas
- Molecular Biology
- Cancer Research
MD Anderson CCSG core facilities
- Flow Cytometry and Cellular Imaging Facility