TY - JOUR
T1 - International society of urological pathology (ISUP) consensus conference on handling and staging of radical prostatectomy specimens. Working group 5
T2 - Surgical margins
AU - Tan, Puay Hoon
AU - Cheng, Liang
AU - Srigley, John R.
AU - Griffiths, David
AU - Humphrey, Peter A.
AU - Van Der Kwast, Theodore H.
AU - Montironi, Rodolfo
AU - Wheeler, Thomas M.
AU - Delahunt, Brett
AU - Egevad, Lars
AU - Epstein, Jonathan I.
AU - The ISUP Prostate Cancer Group
AU - Guo, Charles Chuanhai
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/1
Y1 - 2011/1
N2 - The 2009 International Society of Urological Pathology Consensus Conference in Boston, made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to surgical margin assessment were coordinated by working group 5. Pathologists agreed that tumor extending close to the capsular margin, yet not to it, should be reported as a negative margin, and that locations of positive margins should be indicated as either posterior, posterolateral, lateral, anterior at the prostatic apex, mid-prostate or base. Other items of consensus included specifying the extent of any positive margin as millimeters of involvement; tumor in skeletal muscle at the apical perpendicular margin section, in the absence of accompanying benign glands, to be considered organ confined; and that proximal and distal margins be uniformly referred to as bladder neck and prostatic apex, respectively. Grading of tumor at positive margins was to be left to the discretion of the reporting pathologists. There was no consensus as to how the surgical margin should be regarded when tumor is present at the inked edge of the tissue, in the absence of transected benign glands at the apical margin. Pathologists also did not achieve agreement on the reporting approach to benign prostatic glands at an inked surgical margin in which no carcinoma is present.
AB - The 2009 International Society of Urological Pathology Consensus Conference in Boston, made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to surgical margin assessment were coordinated by working group 5. Pathologists agreed that tumor extending close to the capsular margin, yet not to it, should be reported as a negative margin, and that locations of positive margins should be indicated as either posterior, posterolateral, lateral, anterior at the prostatic apex, mid-prostate or base. Other items of consensus included specifying the extent of any positive margin as millimeters of involvement; tumor in skeletal muscle at the apical perpendicular margin section, in the absence of accompanying benign glands, to be considered organ confined; and that proximal and distal margins be uniformly referred to as bladder neck and prostatic apex, respectively. Grading of tumor at positive margins was to be left to the discretion of the reporting pathologists. There was no consensus as to how the surgical margin should be regarded when tumor is present at the inked edge of the tissue, in the absence of transected benign glands at the apical margin. Pathologists also did not achieve agreement on the reporting approach to benign prostatic glands at an inked surgical margin in which no carcinoma is present.
KW - incision
KW - prostate adenocarcinoma
KW - prostatic apex
KW - radical prostatectomy
KW - surgical margins
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U2 - 10.1038/modpathol.2010.155
DO - 10.1038/modpathol.2010.155
M3 - Review article
C2 - 20729812
AN - SCOPUS:78650858403
SN - 0893-3952
VL - 24
SP - 48
EP - 57
JO - Modern Pathology
JF - Modern Pathology
IS - 1
ER -