Interplay between epigenetic abnormalities and deregulated expression of microRNAs in cancer

Ammad Ahmad Farooqi, Enrique Fuentes-Mattei, Sundas Fayyaz, Priyank Raj, Matthew Goblirsch, Palmiro Poltronieri, George A. Calin

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

Epigenetic abnormalities and aberrant expression of non-coding RNAs are two emerging features of cancer cells, both of which are responsible for deregulated gene expression. In this review, we describe the interplay between the two. Specific themes include epigenetic silencing of tumor suppressor miRNAs, epigenetic activation of oncogenic miRNAs, epigenetic aberrations caused by miRNAs, and naturally occurring compounds which modulate miRNA expression through epigenetic mechanisms.

Original languageEnglish (US)
Pages (from-to)47-55
Number of pages9
JournalSeminars in cancer biology
Volume58
DOIs
StatePublished - Oct 2019

Keywords

  • Epigenetic regulation
  • Non-coding RNAs
  • miRNAs

ASJC Scopus subject areas

  • Cancer Research

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