TY - JOUR
T1 - Interplay between epigenetic abnormalities and deregulated expression of microRNAs in cancer
AU - Farooqi, Ammad Ahmad
AU - Fuentes-Mattei, Enrique
AU - Fayyaz, Sundas
AU - Raj, Priyank
AU - Goblirsch, Matthew
AU - Poltronieri, Palmiro
AU - Calin, George A.
N1 - Publisher Copyright:
© 2019
PY - 2019/10
Y1 - 2019/10
N2 - Epigenetic abnormalities and aberrant expression of non-coding RNAs are two emerging features of cancer cells, both of which are responsible for deregulated gene expression. In this review, we describe the interplay between the two. Specific themes include epigenetic silencing of tumor suppressor miRNAs, epigenetic activation of oncogenic miRNAs, epigenetic aberrations caused by miRNAs, and naturally occurring compounds which modulate miRNA expression through epigenetic mechanisms.
AB - Epigenetic abnormalities and aberrant expression of non-coding RNAs are two emerging features of cancer cells, both of which are responsible for deregulated gene expression. In this review, we describe the interplay between the two. Specific themes include epigenetic silencing of tumor suppressor miRNAs, epigenetic activation of oncogenic miRNAs, epigenetic aberrations caused by miRNAs, and naturally occurring compounds which modulate miRNA expression through epigenetic mechanisms.
KW - Epigenetic regulation
KW - Non-coding RNAs
KW - miRNAs
UR - http://www.scopus.com/inward/record.url?scp=85061707061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061707061&partnerID=8YFLogxK
U2 - 10.1016/j.semcancer.2019.02.003
DO - 10.1016/j.semcancer.2019.02.003
M3 - Review article
C2 - 30742906
AN - SCOPUS:85061707061
SN - 1044-579X
VL - 58
SP - 47
EP - 55
JO - Seminars in cancer biology
JF - Seminars in cancer biology
ER -