Intrahepatic cholangiocarcinoma in Taiwan

Miin Fu Chen, Yi Yin Jan, Long-Bin Jeng, Tsann Long Hwang, Chia Siu Wang, Shin Cheh Chen, Tzu Chieh Chao, Han Ming Chen, Wei Chen Lee, Ta Sen Yeh, Yun Fan Lo

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We report our experience of the surgical treatment of intrahepatic cholangiocarcinoma (ICC) in Taiwanese patients. A total of 162 patients with histologically proven ICC were treated of whom 106 (65.4%) had associated hepatolithiasis. Patients with hepatolithiasis were in earlier stages than those without hepatolithiasis. Two-thirds of the patients with hepatolithiasis presented with acute cholangitis, and two-thirds of those without hepatolithiasis presented with hepatomegaly. The rate of hepatic resection was 29.6% (48 of 162), and these rates were 31.1% and 26.8% for the patients with and without hepatolithiasis, respectively. Ninety-three percent of the patients with hepatolithiasis underwent common bile duct exploration, compared with 18% of those without hepatolithiasis. The surgical mortality rates were 3.7% (6/ 162), for all patients, and 3.8% and 3.6% for patients with and without hepatolithiasis, respectively. The morbidity rate was much higher in the patients with hepatolithiasis (37.7% vs 16.1%). The 1-, 3-, and 5-year survival rates were 35.5%, 20.5%, and 16.5% in the patients with hepatolithiasis and 27.2%, 8.8%, and 7.8% in those without hepatolithiasis. Concomitant hepatolithiasis prevented precise diagnosis preoperatively and precipitated biliary sepsis, which affected resectability and increased postoperative morbidity. Hepatolithiasis per se did not influence long-term survival.

Original languageEnglish (US)
Pages (from-to)136-141
Number of pages6
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Volume6
Issue number2
DOIs
StatePublished - Jan 1 1999

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Cholangiocarcinoma
Taiwan
Morbidity
Cholangitis
Hepatomegaly
Common Bile Duct
Sepsis
Survival Rate
Survival

Keywords

  • Cholangiocellular carcinoma
  • Common bile duct exploration
  • Hepatic resection
  • Hepatolithiasis

ASJC Scopus subject areas

  • Surgery
  • Hepatology

Cite this

Chen, M. F., Jan, Y. Y., Jeng, L-B., Hwang, T. L., Wang, C. S., Chen, S. C., ... Lo, Y. F. (1999). Intrahepatic cholangiocarcinoma in Taiwan. Journal of Hepato-Biliary-Pancreatic Surgery, 6(2), 136-141. https://doi.org/10.1007/s005340050096

Intrahepatic cholangiocarcinoma in Taiwan. / Chen, Miin Fu; Jan, Yi Yin; Jeng, Long-Bin; Hwang, Tsann Long; Wang, Chia Siu; Chen, Shin Cheh; Chao, Tzu Chieh; Chen, Han Ming; Lee, Wei Chen; Yeh, Ta Sen; Lo, Yun Fan.

In: Journal of Hepato-Biliary-Pancreatic Surgery, Vol. 6, No. 2, 01.01.1999, p. 136-141.

Research output: Contribution to journalArticle

Chen, MF, Jan, YY, Jeng, L-B, Hwang, TL, Wang, CS, Chen, SC, Chao, TC, Chen, HM, Lee, WC, Yeh, TS & Lo, YF 1999, 'Intrahepatic cholangiocarcinoma in Taiwan', Journal of Hepato-Biliary-Pancreatic Surgery, vol. 6, no. 2, pp. 136-141. https://doi.org/10.1007/s005340050096
Chen, Miin Fu ; Jan, Yi Yin ; Jeng, Long-Bin ; Hwang, Tsann Long ; Wang, Chia Siu ; Chen, Shin Cheh ; Chao, Tzu Chieh ; Chen, Han Ming ; Lee, Wei Chen ; Yeh, Ta Sen ; Lo, Yun Fan. / Intrahepatic cholangiocarcinoma in Taiwan. In: Journal of Hepato-Biliary-Pancreatic Surgery. 1999 ; Vol. 6, No. 2. pp. 136-141.
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abstract = "We report our experience of the surgical treatment of intrahepatic cholangiocarcinoma (ICC) in Taiwanese patients. A total of 162 patients with histologically proven ICC were treated of whom 106 (65.4{\%}) had associated hepatolithiasis. Patients with hepatolithiasis were in earlier stages than those without hepatolithiasis. Two-thirds of the patients with hepatolithiasis presented with acute cholangitis, and two-thirds of those without hepatolithiasis presented with hepatomegaly. The rate of hepatic resection was 29.6{\%} (48 of 162), and these rates were 31.1{\%} and 26.8{\%} for the patients with and without hepatolithiasis, respectively. Ninety-three percent of the patients with hepatolithiasis underwent common bile duct exploration, compared with 18{\%} of those without hepatolithiasis. The surgical mortality rates were 3.7{\%} (6/ 162), for all patients, and 3.8{\%} and 3.6{\%} for patients with and without hepatolithiasis, respectively. The morbidity rate was much higher in the patients with hepatolithiasis (37.7{\%} vs 16.1{\%}). The 1-, 3-, and 5-year survival rates were 35.5{\%}, 20.5{\%}, and 16.5{\%} in the patients with hepatolithiasis and 27.2{\%}, 8.8{\%}, and 7.8{\%} in those without hepatolithiasis. Concomitant hepatolithiasis prevented precise diagnosis preoperatively and precipitated biliary sepsis, which affected resectability and increased postoperative morbidity. Hepatolithiasis per se did not influence long-term survival.",
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AU - Chao, Tzu Chieh

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N2 - We report our experience of the surgical treatment of intrahepatic cholangiocarcinoma (ICC) in Taiwanese patients. A total of 162 patients with histologically proven ICC were treated of whom 106 (65.4%) had associated hepatolithiasis. Patients with hepatolithiasis were in earlier stages than those without hepatolithiasis. Two-thirds of the patients with hepatolithiasis presented with acute cholangitis, and two-thirds of those without hepatolithiasis presented with hepatomegaly. The rate of hepatic resection was 29.6% (48 of 162), and these rates were 31.1% and 26.8% for the patients with and without hepatolithiasis, respectively. Ninety-three percent of the patients with hepatolithiasis underwent common bile duct exploration, compared with 18% of those without hepatolithiasis. The surgical mortality rates were 3.7% (6/ 162), for all patients, and 3.8% and 3.6% for patients with and without hepatolithiasis, respectively. The morbidity rate was much higher in the patients with hepatolithiasis (37.7% vs 16.1%). The 1-, 3-, and 5-year survival rates were 35.5%, 20.5%, and 16.5% in the patients with hepatolithiasis and 27.2%, 8.8%, and 7.8% in those without hepatolithiasis. Concomitant hepatolithiasis prevented precise diagnosis preoperatively and precipitated biliary sepsis, which affected resectability and increased postoperative morbidity. Hepatolithiasis per se did not influence long-term survival.

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