Intratumoral mast cells promote the growth of pancreatic cancer

Ying Ma; Stephen E. Ullrich

doi:10.4161/onci.25964

Intratumoral mast cells promote the growth of pancreatic cancer

Ying Ma, Stephen E. Ullrich

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We have recently discovered that mast cells promote pancreatic tumorigenesis by exacerbating the cellular and extracellular signaling in the desmoplastic microenvironment. Our findings demonstrate for the first time that targeting mast cells can block the progression of pancreatic neoplasms and prolong the survival of tumor-bearing immunocompetent hosts.

Original language	English (US)
Article number	e25913
Journal	OncoImmunology
Volume	2
Issue number	10
DOIs	https://doi.org/10.4161/onci.25964
State	Published - 2013

Keywords

Mast cells
Pancreatic cancer
Pancreatic stellate cells
Tumor microenvironment

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.25964

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title = "Intratumoral mast cells promote the growth of pancreatic cancer",

abstract = "We have recently discovered that mast cells promote pancreatic tumorigenesis by exacerbating the cellular and extracellular signaling in the desmoplastic microenvironment. Our findings demonstrate for the first time that targeting mast cells can block the progression of pancreatic neoplasms and prolong the survival of tumor-bearing immunocompetent hosts.",

keywords = "Mast cells, Pancreatic cancer, Pancreatic stellate cells, Tumor microenvironment",

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AU - Ullrich, Stephen E.

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KW - Mast cells

KW - Pancreatic cancer

KW - Pancreatic stellate cells

KW - Tumor microenvironment

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JO - OncoImmunology

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Intratumoral mast cells promote the growth of pancreatic cancer

Abstract

Keywords

ASJC Scopus subject areas

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