Intravascular photoacoustic imaging of gold-nanorod labeled atherosclerotic plaques

Doug Yeager; Andrei Karpiouk; Bo Wang; James Amirian; Konstantin Sokolov; Richard Smalling; Stanislav Emelianov

doi:10.1117/12.907125

Intravascular photoacoustic imaging of gold-nanorod labeled atherosclerotic plaques

Doug Yeager, Andrei Karpiouk, Bo Wang, James Amirian, Konstantin Sokolov, Richard Smalling, Stanislav Emelianov

Imaging Physics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Combined intravascular photoacoustic (IVPA) and intravascular ultrasound (IVUS) imaging has been previously established as a viable means for imaging atherosclerotic plaques using both endogenous and exogenous contrast. In this study, IVUS/IVPA imaging of an atherosclerotic rabbit aorta following injection of gold nanorods (AuNR) with peak absorbance within the tissue optical window was performed. Ex-vivo imaging results revealed high photoacoustic signal from localized AuNR. Corresponding histological cross-sections and digital photographs of the arterial lumen confirmed the presence of AuNR preferentially located at atherosclerotic regions and in agreement with IVPA signal. Furthermore, an integrated IVUS/IVPA imaging catheter was used to image the AuNR in the presence of luminal blood. The results suggest that AuNR allow for IVPA imaging of exogenously labeled atherosclerotic plaques with a comparatively low background signal and without the need for arterial blood flushing.

Original language	English (US)
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2012
DOIs	https://doi.org/10.1117/12.907125
State	Published - 2012
Event	Photons Plus Ultrasound: Imaging and Sensing 2012 - San Francisco, CA, United States Duration: Jan 22 2012 → Jan 24 2012

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	8223
ISSN (Print)	1605-7422

Other

Other	Photons Plus Ultrasound: Imaging and Sensing 2012
Country/Territory	United States
City	San Francisco, CA
Period	1/22/12 → 1/24/12

Keywords

Atherosclerosis
Gold nanoparticles
Gold nanorods
Intravascular imaging
Intravascular ultrasound
Photoacoustic
Spectroscopic imaging

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

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10.1117/12.907125

Cite this

Yeager, D, Karpiouk, A, Wang, B, Amirian, J, Sokolov, K, Smalling, R & Emelianov, S 2012, Intravascular photoacoustic imaging of gold-nanorod labeled atherosclerotic plaques. in Photons Plus Ultrasound: Imaging and Sensing 2012., 82231Q, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, San Francisco, CA, United States, 1/22/12. https://doi.org/10.1117/12.907125

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title = "Intravascular photoacoustic imaging of gold-nanorod labeled atherosclerotic plaques",

abstract = "Combined intravascular photoacoustic (IVPA) and intravascular ultrasound (IVUS) imaging has been previously established as a viable means for imaging atherosclerotic plaques using both endogenous and exogenous contrast. In this study, IVUS/IVPA imaging of an atherosclerotic rabbit aorta following injection of gold nanorods (AuNR) with peak absorbance within the tissue optical window was performed. Ex-vivo imaging results revealed high photoacoustic signal from localized AuNR. Corresponding histological cross-sections and digital photographs of the arterial lumen confirmed the presence of AuNR preferentially located at atherosclerotic regions and in agreement with IVPA signal. Furthermore, an integrated IVUS/IVPA imaging catheter was used to image the AuNR in the presence of luminal blood. The results suggest that AuNR allow for IVPA imaging of exogenously labeled atherosclerotic plaques with a comparatively low background signal and without the need for arterial blood flushing.",

keywords = "Atherosclerosis, Gold nanoparticles, Gold nanorods, Intravascular imaging, Intravascular ultrasound, Photoacoustic, Spectroscopic imaging",

author = "Doug Yeager and Andrei Karpiouk and Bo Wang and James Amirian and Konstantin Sokolov and Richard Smalling and Stanislav Emelianov",

year = "2012",

doi = "10.1117/12.907125",

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AU - Yeager, Doug

AU - Karpiouk, Andrei

AU - Wang, Bo

AU - Amirian, James

AU - Sokolov, Konstantin

AU - Smalling, Richard

AU - Emelianov, Stanislav

PY - 2012

Y1 - 2012

N2 - Combined intravascular photoacoustic (IVPA) and intravascular ultrasound (IVUS) imaging has been previously established as a viable means for imaging atherosclerotic plaques using both endogenous and exogenous contrast. In this study, IVUS/IVPA imaging of an atherosclerotic rabbit aorta following injection of gold nanorods (AuNR) with peak absorbance within the tissue optical window was performed. Ex-vivo imaging results revealed high photoacoustic signal from localized AuNR. Corresponding histological cross-sections and digital photographs of the arterial lumen confirmed the presence of AuNR preferentially located at atherosclerotic regions and in agreement with IVPA signal. Furthermore, an integrated IVUS/IVPA imaging catheter was used to image the AuNR in the presence of luminal blood. The results suggest that AuNR allow for IVPA imaging of exogenously labeled atherosclerotic plaques with a comparatively low background signal and without the need for arterial blood flushing.

AB - Combined intravascular photoacoustic (IVPA) and intravascular ultrasound (IVUS) imaging has been previously established as a viable means for imaging atherosclerotic plaques using both endogenous and exogenous contrast. In this study, IVUS/IVPA imaging of an atherosclerotic rabbit aorta following injection of gold nanorods (AuNR) with peak absorbance within the tissue optical window was performed. Ex-vivo imaging results revealed high photoacoustic signal from localized AuNR. Corresponding histological cross-sections and digital photographs of the arterial lumen confirmed the presence of AuNR preferentially located at atherosclerotic regions and in agreement with IVPA signal. Furthermore, an integrated IVUS/IVPA imaging catheter was used to image the AuNR in the presence of luminal blood. The results suggest that AuNR allow for IVPA imaging of exogenously labeled atherosclerotic plaques with a comparatively low background signal and without the need for arterial blood flushing.

KW - Atherosclerosis

KW - Gold nanoparticles

KW - Gold nanorods

KW - Intravascular imaging

KW - Intravascular ultrasound

KW - Photoacoustic

KW - Spectroscopic imaging

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M3 - Conference contribution

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T2 - Photons Plus Ultrasound: Imaging and Sensing 2012

Y2 - 22 January 2012 through 24 January 2012

ER -

Intravascular photoacoustic imaging of gold-nanorod labeled atherosclerotic plaques

Abstract

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Keywords

ASJC Scopus subject areas

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