Invasion of the hypoglossal nerve by adenoid cystic carcinoma of the tongue: Case report and review of the literature

Shu Wei Chen, Zhu Ming Guo, Quan Zhang, An Kui Yang, Qiu Li Li, Shi Min Zhuang, Li Ping Wang, Ming Song

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Adenoid cystic carcinoma (ACC) is a rare but highly aggressive malignancy mainly originating from the salivary glands. ACC is well known for its propensity toward neural invasion (NI). NI is the process of neoplastic invasion in and along nerves. It is a distinct and welldocumented phenomenon in ACC;however, it is an underestimated route of metastatic spread. Multiple distant metastases can be established through NI route, and NI is believed to portend a poor prognosis. Despite increasing recognition of NI in many malignancies, the molecular mechanism behind NI is not well established. We present a unique case of hypoglossal nerve invasion by ACC arising from the minor salivary glands in the tongue of a 34-yearold man. We also review and discuss current theories on the pathogenesis and mechanism of NI.

Original languageEnglish (US)
Pages (from-to)965-968
Number of pages4
JournalPathology and Oncology Research
Volume17
Issue number4
DOIs
StatePublished - Dec 1 2011

Fingerprint

Hypoglossal Nerve
Adenoid Cystic Carcinoma
Tongue
Minor Salivary Glands
Neoplastic Processes
Salivary Glands
Neoplasms
Neoplasm Metastasis

Keywords

  • Adenoid cystic carcinoma
  • Hypoglossal nerve
  • Neural invasion
  • Tongue
  • Treatment

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Cite this

Invasion of the hypoglossal nerve by adenoid cystic carcinoma of the tongue : Case report and review of the literature. / Chen, Shu Wei; Guo, Zhu Ming; Zhang, Quan; Yang, An Kui; Li, Qiu Li; Zhuang, Shi Min; Wang, Li Ping; Song, Ming.

In: Pathology and Oncology Research, Vol. 17, No. 4, 01.12.2011, p. 965-968.

Research output: Contribution to journalReview article

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T2 - Case report and review of the literature

AU - Chen, Shu Wei

AU - Guo, Zhu Ming

AU - Zhang, Quan

AU - Yang, An Kui

AU - Li, Qiu Li

AU - Zhuang, Shi Min

AU - Wang, Li Ping

AU - Song, Ming

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N2 - Adenoid cystic carcinoma (ACC) is a rare but highly aggressive malignancy mainly originating from the salivary glands. ACC is well known for its propensity toward neural invasion (NI). NI is the process of neoplastic invasion in and along nerves. It is a distinct and welldocumented phenomenon in ACC;however, it is an underestimated route of metastatic spread. Multiple distant metastases can be established through NI route, and NI is believed to portend a poor prognosis. Despite increasing recognition of NI in many malignancies, the molecular mechanism behind NI is not well established. We present a unique case of hypoglossal nerve invasion by ACC arising from the minor salivary glands in the tongue of a 34-yearold man. We also review and discuss current theories on the pathogenesis and mechanism of NI.

AB - Adenoid cystic carcinoma (ACC) is a rare but highly aggressive malignancy mainly originating from the salivary glands. ACC is well known for its propensity toward neural invasion (NI). NI is the process of neoplastic invasion in and along nerves. It is a distinct and welldocumented phenomenon in ACC;however, it is an underestimated route of metastatic spread. Multiple distant metastases can be established through NI route, and NI is believed to portend a poor prognosis. Despite increasing recognition of NI in many malignancies, the molecular mechanism behind NI is not well established. We present a unique case of hypoglossal nerve invasion by ACC arising from the minor salivary glands in the tongue of a 34-yearold man. We also review and discuss current theories on the pathogenesis and mechanism of NI.

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