TY - JOUR
T1 - Investigation of tissue cellularity at the tip of the core biopsy needle with optical coherence tomography
AU - Iftimia, Nicusor
AU - Park, Jesung
AU - Maguluri, Gopi
AU - Krishnamurthy, Savitri
AU - McWatters, Amanda
AU - Sabir, Sharjeel H.
N1 - Funding Information:
NIH/NCI #HHSN261201600030C
Publisher Copyright:
© 2018 Optical Society of America.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - We report the development and the pre-clinical testing of a new technology based on optical coherence tomography (OCT) for investigating tissue composition at the tip of the core biopsy needle. While ultrasound, computed tomography, and magnetic resonance imaging are routinely used to guide needle placement within a tumor, they still do not provide the resolution needed to investigate tissue cellularity (ratio between viable tumor and benign stroma) at the needle tip prior to taking a biopsy core. High resolution OCT imaging, however, can be used to investigate tissue morphology at the micron scale, and thus to determine if the biopsy core would likely have the expected composition. Therefore, we implemented this capability within a custom-made biopsy gun and evaluated its capability for a correct estimation of tumor tissue cellularity. A pilot study on a rabbit model of soft tissue cancer has shown the capability of this technique to provide correct evaluation of tumor tissue cellularity in over 85% of the cases. These initial results indicate the potential benefit of the OCT-based approach for improving the success of the core biopsy procedures.
AB - We report the development and the pre-clinical testing of a new technology based on optical coherence tomography (OCT) for investigating tissue composition at the tip of the core biopsy needle. While ultrasound, computed tomography, and magnetic resonance imaging are routinely used to guide needle placement within a tumor, they still do not provide the resolution needed to investigate tissue cellularity (ratio between viable tumor and benign stroma) at the needle tip prior to taking a biopsy core. High resolution OCT imaging, however, can be used to investigate tissue morphology at the micron scale, and thus to determine if the biopsy core would likely have the expected composition. Therefore, we implemented this capability within a custom-made biopsy gun and evaluated its capability for a correct estimation of tumor tissue cellularity. A pilot study on a rabbit model of soft tissue cancer has shown the capability of this technique to provide correct evaluation of tumor tissue cellularity in over 85% of the cases. These initial results indicate the potential benefit of the OCT-based approach for improving the success of the core biopsy procedures.
UR - http://www.scopus.com/inward/record.url?scp=85041500491&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041500491&partnerID=8YFLogxK
U2 - 10.1364/BOE.9.000694
DO - 10.1364/BOE.9.000694
M3 - Article
C2 - 29552405
AN - SCOPUS:85041500491
SN - 2156-7085
VL - 9
SP - 694
EP - 704
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 2
M1 - #314937
ER -