Involuntary smoking and the risk of head and neck cancer in an East Asian population

Mia Hashibe, Qian Li, Chien Jen Chen, Wan Lun Hsu, Pei Jen Lou, Cairong Zhu, Jian Pan, Hongbing Shen, Hongxia Ma, Lin Cai, Baochang He, Yu Wang, Xiaoyan Zhou, Qinghai Ji, Baosen Zhou, Wei Wu, Jie Ma, Paolo Boffetta, Zuo Feng Zhang, Min DaiYuan Chin Amy Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Although tobacco involuntary smoking is an established risk factor for lung cancer, the association with head and neck cancer (HNC) is not established. We aimed to investigate this potential association in an East Asian population. Methods: We conducted a multicenter case-control study in East Asia including eight centers. We restricted our analysis to never tobacco smokers (303 cases and 459 controls) and to never tobacco smokers/never alcohol drinkers (243 cases and 403 controls). Results: Among never tobacco smokers, involuntary smoking was associated with a 1.47-fold increase in risk of HNC (95%CI = 1.02, 2.13) and a 1.8-fold increase in the risk of oral cavity cancer (95%CI = 1.14, 2.92). Among never tobacco smokers who were also never alcohol drinkers, increased risks were detected for more than 3 h per day of involuntary smoking exposure and for 15 or more years of exposure. A dose-response relation was suggested for frequency of exposure (p for trend = 0.014) and for years of exposure (p for trend = 0.010) for oral cavity cancer. We did not detect strong increases in the risk of the other HNC subsites. Conclusions: Our study supports the association between involuntary smoking and the risk of HNC. The association may be stronger for oral cavity cancer than for other HNC subsites.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalCancer Epidemiology
Volume59
DOIs
StatePublished - Apr 2019

Fingerprint

Tobacco Smoke Pollution
Head and Neck Neoplasms
Tobacco
Mouth Neoplasms
Population
Mouth
Alcohols
Far East
Case-Control Studies
Lung Neoplasms
Smoking

Keywords

  • Head and neck cancer
  • Involuntary smoking
  • Never alcohol drinkers
  • Never tobacco smokers

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Cancer Research

Cite this

Hashibe, M., Li, Q., Chen, C. J., Hsu, W. L., Lou, P. J., Zhu, C., ... Lee, Y. C. A. (2019). Involuntary smoking and the risk of head and neck cancer in an East Asian population. Cancer Epidemiology, 59, 173-177. https://doi.org/10.1016/j.canep.2019.01.020

Involuntary smoking and the risk of head and neck cancer in an East Asian population. / Hashibe, Mia; Li, Qian; Chen, Chien Jen; Hsu, Wan Lun; Lou, Pei Jen; Zhu, Cairong; Pan, Jian; Shen, Hongbing; Ma, Hongxia; Cai, Lin; He, Baochang; Wang, Yu; Zhou, Xiaoyan; Ji, Qinghai; Zhou, Baosen; Wu, Wei; Ma, Jie; Boffetta, Paolo; Zhang, Zuo Feng; Dai, Min; Lee, Yuan Chin Amy.

In: Cancer Epidemiology, Vol. 59, 04.2019, p. 173-177.

Research output: Contribution to journalArticle

Hashibe, M, Li, Q, Chen, CJ, Hsu, WL, Lou, PJ, Zhu, C, Pan, J, Shen, H, Ma, H, Cai, L, He, B, Wang, Y, Zhou, X, Ji, Q, Zhou, B, Wu, W, Ma, J, Boffetta, P, Zhang, ZF, Dai, M & Lee, YCA 2019, 'Involuntary smoking and the risk of head and neck cancer in an East Asian population', Cancer Epidemiology, vol. 59, pp. 173-177. https://doi.org/10.1016/j.canep.2019.01.020
Hashibe, Mia ; Li, Qian ; Chen, Chien Jen ; Hsu, Wan Lun ; Lou, Pei Jen ; Zhu, Cairong ; Pan, Jian ; Shen, Hongbing ; Ma, Hongxia ; Cai, Lin ; He, Baochang ; Wang, Yu ; Zhou, Xiaoyan ; Ji, Qinghai ; Zhou, Baosen ; Wu, Wei ; Ma, Jie ; Boffetta, Paolo ; Zhang, Zuo Feng ; Dai, Min ; Lee, Yuan Chin Amy. / Involuntary smoking and the risk of head and neck cancer in an East Asian population. In: Cancer Epidemiology. 2019 ; Vol. 59. pp. 173-177.
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abstract = "Background: Although tobacco involuntary smoking is an established risk factor for lung cancer, the association with head and neck cancer (HNC) is not established. We aimed to investigate this potential association in an East Asian population. Methods: We conducted a multicenter case-control study in East Asia including eight centers. We restricted our analysis to never tobacco smokers (303 cases and 459 controls) and to never tobacco smokers/never alcohol drinkers (243 cases and 403 controls). Results: Among never tobacco smokers, involuntary smoking was associated with a 1.47-fold increase in risk of HNC (95{\%}CI = 1.02, 2.13) and a 1.8-fold increase in the risk of oral cavity cancer (95{\%}CI = 1.14, 2.92). Among never tobacco smokers who were also never alcohol drinkers, increased risks were detected for more than 3 h per day of involuntary smoking exposure and for 15 or more years of exposure. A dose-response relation was suggested for frequency of exposure (p for trend = 0.014) and for years of exposure (p for trend = 0.010) for oral cavity cancer. We did not detect strong increases in the risk of the other HNC subsites. Conclusions: Our study supports the association between involuntary smoking and the risk of HNC. The association may be stronger for oral cavity cancer than for other HNC subsites.",
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AU - Hashibe, Mia

AU - Li, Qian

AU - Chen, Chien Jen

AU - Hsu, Wan Lun

AU - Lou, Pei Jen

AU - Zhu, Cairong

AU - Pan, Jian

AU - Shen, Hongbing

AU - Ma, Hongxia

AU - Cai, Lin

AU - He, Baochang

AU - Wang, Yu

AU - Zhou, Xiaoyan

AU - Ji, Qinghai

AU - Zhou, Baosen

AU - Wu, Wei

AU - Ma, Jie

AU - Boffetta, Paolo

AU - Zhang, Zuo Feng

AU - Dai, Min

AU - Lee, Yuan Chin Amy

PY - 2019/4

Y1 - 2019/4

N2 - Background: Although tobacco involuntary smoking is an established risk factor for lung cancer, the association with head and neck cancer (HNC) is not established. We aimed to investigate this potential association in an East Asian population. Methods: We conducted a multicenter case-control study in East Asia including eight centers. We restricted our analysis to never tobacco smokers (303 cases and 459 controls) and to never tobacco smokers/never alcohol drinkers (243 cases and 403 controls). Results: Among never tobacco smokers, involuntary smoking was associated with a 1.47-fold increase in risk of HNC (95%CI = 1.02, 2.13) and a 1.8-fold increase in the risk of oral cavity cancer (95%CI = 1.14, 2.92). Among never tobacco smokers who were also never alcohol drinkers, increased risks were detected for more than 3 h per day of involuntary smoking exposure and for 15 or more years of exposure. A dose-response relation was suggested for frequency of exposure (p for trend = 0.014) and for years of exposure (p for trend = 0.010) for oral cavity cancer. We did not detect strong increases in the risk of the other HNC subsites. Conclusions: Our study supports the association between involuntary smoking and the risk of HNC. The association may be stronger for oral cavity cancer than for other HNC subsites.

AB - Background: Although tobacco involuntary smoking is an established risk factor for lung cancer, the association with head and neck cancer (HNC) is not established. We aimed to investigate this potential association in an East Asian population. Methods: We conducted a multicenter case-control study in East Asia including eight centers. We restricted our analysis to never tobacco smokers (303 cases and 459 controls) and to never tobacco smokers/never alcohol drinkers (243 cases and 403 controls). Results: Among never tobacco smokers, involuntary smoking was associated with a 1.47-fold increase in risk of HNC (95%CI = 1.02, 2.13) and a 1.8-fold increase in the risk of oral cavity cancer (95%CI = 1.14, 2.92). Among never tobacco smokers who were also never alcohol drinkers, increased risks were detected for more than 3 h per day of involuntary smoking exposure and for 15 or more years of exposure. A dose-response relation was suggested for frequency of exposure (p for trend = 0.014) and for years of exposure (p for trend = 0.010) for oral cavity cancer. We did not detect strong increases in the risk of the other HNC subsites. Conclusions: Our study supports the association between involuntary smoking and the risk of HNC. The association may be stronger for oral cavity cancer than for other HNC subsites.

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