Involvement of microRNA-93, a new regulator of PTEN/Akt signaling pathway, in regulation of chemotherapeutic drug cisplatin chemosensitivity in ovarian cancer cells

Xin Fu, Jing Tian, Lei Zhang, Ying Chen, Quan Hao

    Research output: Contribution to journalArticle

    136 Scopus citations

    Abstract

    The mechanisms underlying ovarian cancer cell resistance to cisplatin (CDDP) are not fully understood. MicroRNAs (miRNAs) play important roles in tumorigenesis and drug resistance. In this paper, we utilized microRNA array and real-time PCR to show that miR-93 is significantly up-regulated in cisplatin-resistant ovarian cancer cells. In vitro assays show that over-expression and knock-down of miR-93 regulate apoptotic activity, and thereby cisplatin chemosensitivity, in ovarian cells. Furthermore, we found that miR-93 can directly target PTEN, and participates in the regulation of the AKT signaling pathway. MiR-93 inversely correlates with PTEN expression in CDDP-resistant and sensitive human ovarian cancer tissues. These results may have implications for therapeutic strategies aiming to overcome ovarian cancer cell resistance to cisplatin.

    Original languageEnglish (US)
    Pages (from-to)1279-1286
    Number of pages8
    JournalFEBS Letters
    Volume586
    Issue number9
    DOIs
    StatePublished - May 7 2012

    Keywords

    • Cisplatin
    • Drug resistance
    • Human ovarian cancer
    • MicroRNA-93
    • PTEN

    ASJC Scopus subject areas

    • Biophysics
    • Structural Biology
    • Biochemistry
    • Molecular Biology
    • Genetics
    • Cell Biology

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