Involvement of MicroRNAs in human cancer: Discovery and expression profiling

Massimo Negrini, George A. Calin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The initial discovery of the involvement of two microRNAs, miR-15a and miR-16-1, in human CLL opened the way to the myriad of studies that have now conclusively proved the central role of microRNAs in all human cancers. Gene expression studies revealed that hundreds of microRNAs are deregulated in cancer cells and functional studies clarified that microRNAs are involved in all the molecular and biological processes that drive tumorigenesis. These findings have greatly improved our understanding on the molecular basis of cancer and, even more importantly, laid the foundation for the exploitation of microRNAs in cancer therapy.

Original languageEnglish (US)
Title of host publicationAn Omics Perspective on Cancer Research
PublisherSpringer Netherlands
Pages69-104
Number of pages36
ISBN (Print)9789048126743
DOIs
StatePublished - 2010

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

Fingerprint

Dive into the research topics of 'Involvement of MicroRNAs in human cancer: Discovery and expression profiling'. Together they form a unique fingerprint.

Cite this