TY - JOUR
T1 - Is a matched unrelated donor search needed for all allogeneic transplant candidates?
AU - Ciurea, Stefan O.
AU - Bittencourt, Maria Cecilia Borges
AU - Milton, Denái R.
AU - Cao, Kai
AU - Kongtim, Piyanuch
AU - Rondon, Gabriela
AU - Chen, Julianne
AU - Konopleva, Marina
AU - Ramos Perez, Jorge M.
AU - El Shazly, Mohammed F.
AU - Aljadayeh, Majdi
AU - Alvarez, Michele
AU - Im, Jin
AU - Al-Atrash, Gheath
AU - Mehta, Rohtesh
AU - Popat, Uday
AU - Bashir, Qaiser
AU - Oran, Betul
AU - Hosing, Chitra M.
AU - Khouri, Issa F.
AU - Kebriaei, Partow
AU - Champlin, Richard E.
N1 - Publisher Copyright:
© 2018 by The American Society of Hematology.
PY - 2018/9/11
Y1 - 2018/9/11
N2 - Donor availability for allogeneic transplantation remains an important factor in determining outcomes of a successful transplant. We examined outcomes of 242 patients treated over 3 years who had a matched unrelated donor (MUD) search at our institution. One hundred sixty patients (66%) had a 10 of 10 MUD identified, and 85 (53%) proceeded to MUD transplantation. White patients and those with common haplotypes were more likely to have a MUD identified (odds ratio [OR], 7.4 [P, .0001]; OR, 41.6 [P, .0001]), and were more likely to proceed to transplantation with a MUD (OR, 11.2 [P, .0001]; OR, 85.1 [P 5 .002]). In addition, patients who were newly diagnosed/in remission at the time of MUD search had a higher probability of receiving a transplant (OR, 2.01 [P 5 .013]) and better progression-free survival (PFS; P, .0001). In multivariate analysis for patients who received a transplant, donor type did not influence PFS at 3 years, which was 40% for MUD and 57% for haploidentical transplants, respectively (hazard ratio, 1.2 [P 5 .50]). In conclusion, race, haplotype frequency, and disease status at the time of MUD search influence the probability of identifying a MUD and receiving a transplant. Patients with a low likelihood of receiving a MUD transplant may proceed to a haploidentical transplant as soon as indicated, as this approach does not appear to compromise transplant outcomes.
AB - Donor availability for allogeneic transplantation remains an important factor in determining outcomes of a successful transplant. We examined outcomes of 242 patients treated over 3 years who had a matched unrelated donor (MUD) search at our institution. One hundred sixty patients (66%) had a 10 of 10 MUD identified, and 85 (53%) proceeded to MUD transplantation. White patients and those with common haplotypes were more likely to have a MUD identified (odds ratio [OR], 7.4 [P, .0001]; OR, 41.6 [P, .0001]), and were more likely to proceed to transplantation with a MUD (OR, 11.2 [P, .0001]; OR, 85.1 [P 5 .002]). In addition, patients who were newly diagnosed/in remission at the time of MUD search had a higher probability of receiving a transplant (OR, 2.01 [P 5 .013]) and better progression-free survival (PFS; P, .0001). In multivariate analysis for patients who received a transplant, donor type did not influence PFS at 3 years, which was 40% for MUD and 57% for haploidentical transplants, respectively (hazard ratio, 1.2 [P 5 .50]). In conclusion, race, haplotype frequency, and disease status at the time of MUD search influence the probability of identifying a MUD and receiving a transplant. Patients with a low likelihood of receiving a MUD transplant may proceed to a haploidentical transplant as soon as indicated, as this approach does not appear to compromise transplant outcomes.
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U2 - 10.1182/pbloodadvances.2018021899
DO - 10.1182/pbloodadvances.2018021899
M3 - Article
C2 - 30206098
AN - SCOPUS:85065446465
SN - 2473-9529
VL - 2
SP - 2254
EP - 2261
JO - Blood Advances
JF - Blood Advances
IS - 17
ER -