Abstract
In addition to free extracellular DNA, blood plasma also contains nucleic acids encased in vesicles with lipid bilayer membranes. These can be divided into exosomes and extracellular vesicles, and although the two types overlap in some markers and physical properties, they are generated by different mechanisms. Exosomes can be actively secreted from cells, including cancer cells, and the stability of their cargo makes them a promising source of biomarker targets. In this chapter, we describe the origins, isolation strategies, nucleic acid content, and biomarker potential of exosomes.
| Original language | English (US) |
|---|---|
| Title of host publication | Cell-Free Circulating DNA |
| Subtitle of host publication | Purification and Analysis Techniques |
| Publisher | World Scientific Publishing Co. |
| Pages | 209-246 |
| Number of pages | 38 |
| ISBN (Electronic) | 9789811244681 |
| ISBN (Print) | 9789811244674 |
| DOIs | |
| State | Published - Jan 1 2022 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Agricultural and Biological Sciences
- General Medicine