JmjC lysine demethylases

Xiaodong Cheng, Raymond C. Trievel

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations

Abstract

Among the most fundamental questions in the regulation of gene expression in mammals is how epigenetic methylation patterns of histone lysine residues are established, recognized and erased. This chapter reviews recent studies on, and discusses the resulting biochemical and structural insights into, the Jumonji C (JmjC)-containing lysine demethylases (KDMs), focusing on their biological functions, three-dimensional structures, mechanism and substrate specificities.

Original languageEnglish (US)
Title of host publication2-Oxoglutarate-Dependent Oxygenases
EditorsRobert P. Hausinger, Christopher J. Schofield
PublisherRoyal Society of Chemistry
Pages210-245
Number of pages36
Edition3
DOIs
StatePublished - 2015
Externally publishedYes

Publication series

NameRSC Metallobiology
Number3
Volume2015-January
ISSN (Print)2045-547X

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

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