Ketone bodies as guardians of leukemic stemness through ferroptosis suppression

Xi Zhao; Li Zhuang; Boyi Gan

doi:10.1016/j.stem.2026.04.022

Ketone bodies as guardians of leukemic stemness through ferroptosis suppression

Xi Zhao
, Li Zhuang
, Boyi Gan

Experimental Radiation Oncology

Research output: Contribution to journal › Article › peer-review

Abstract

Leukemia stem cells exploit cell-intrinsic ketogenesis to suppress ferroptosis and sustain disease propagation. In this issue, Han et al.1 uncover a β-hydroxybutyrate-epigenetic-lipid remodeling axis that protects stemness by restraining ferroptosis, revealing a metabolic vulnerability with therapeutic potential.

Original language	English (US)
Pages (from-to)	901-903
Number of pages	3
Journal	Cell Stem Cell
Volume	33
Issue number	6
DOIs	https://doi.org/10.1016/j.stem.2026.04.022
State	Published - Jun 4 2026

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2026.04.022

Cite this

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title = "Ketone bodies as guardians of leukemic stemness through ferroptosis suppression",

abstract = "Leukemia stem cells exploit cell-intrinsic ketogenesis to suppress ferroptosis and sustain disease propagation. In this issue, Han et al.1 uncover a β-hydroxybutyrate-epigenetic-lipid remodeling axis that protects stemness by restraining ferroptosis, revealing a metabolic vulnerability with therapeutic potential.",

author = "Xi Zhao and Li Zhuang and Boyi Gan",

year = "2026",

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T1 - Ketone bodies as guardians of leukemic stemness through ferroptosis suppression

AU - Zhao, Xi

AU - Zhuang, Li

AU - Gan, Boyi

PY - 2026/6/4

Y1 - 2026/6/4

N2 - Leukemia stem cells exploit cell-intrinsic ketogenesis to suppress ferroptosis and sustain disease propagation. In this issue, Han et al.1 uncover a β-hydroxybutyrate-epigenetic-lipid remodeling axis that protects stemness by restraining ferroptosis, revealing a metabolic vulnerability with therapeutic potential.

AB - Leukemia stem cells exploit cell-intrinsic ketogenesis to suppress ferroptosis and sustain disease propagation. In this issue, Han et al.1 uncover a β-hydroxybutyrate-epigenetic-lipid remodeling axis that protects stemness by restraining ferroptosis, revealing a metabolic vulnerability with therapeutic potential.

UR - https://www.scopus.com/pages/publications/105041470346

UR - https://www.scopus.com/pages/publications/105041470346#tab=citedBy

U2 - 10.1016/j.stem.2026.04.022

DO - 10.1016/j.stem.2026.04.022

M3 - Article

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AN - SCOPUS:105041470346

SN - 1934-5909

VL - 33

SP - 901

EP - 903

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 6

ER -

Ketone bodies as guardians of leukemic stemness through ferroptosis suppression

Abstract

ASJC Scopus subject areas

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