Kinetics of gallium nitrate, a new anticancer agent

Stephen W. Hall, Katherine Yeung, Robert S. Benjamin, David Stewart, Manuel Valdivieso, Agop Y. Bedikian, Ti Li Loo

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

]Pharmacokinetic studies were conducted in 8 patients with disseminated neoplasms refractory to conventional chemotherapy, who received gallium nitrate at doses of 300 to 600 mg/m2 intravenously in a phase I clinical trial. Gallium concentrations in biological fluids were determined colorimetrically. In patients with normal renal funetion, gallium showed a biphasic plasma disappearance with an initial haf-life (t 1 2) of 0.5 to 1.8 hr (mean 1.0) and a terminal t 1 2 of 10.5 to 50.4 hr (mean 25.1). Gallium was distributed in total body water and often localized in some body compartment as evidenced by a volume of distribution ranging from 0.25 to 2.53 L/kg (mean 1.19). The total drug clearance from the plasma was 0.13 to 1.00 ml/kg/min (mean 0.65) in patients with normal renal function. Cumulative urinary excretion of gallium was 15% to 72% (mean 35%) of the administered dose in 24 hr (it fell to 23% in 8 days in a patient with acute oliguric renal failure). Gallium kinetics are altered in patients with acute renal dysfunction and in patients who have received multiple doses of gallium or other metal chemotherapy.

Original languageEnglish (US)
Pages (from-to)82-87
Number of pages6
JournalClinical pharmacology and therapeutics
Volume25
Issue number1
DOIs
StatePublished - Jan 1979

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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