L-Asparaginase

John P. Whitecar, Gerald P. Bodey, Jules E. Harris, Emil J. Freireich

Research output: Contribution to journalReview articlepeer-review

129 Scopus citations

Abstract

L-Asparaginase affords a unique approach to the chemotherapy of malignant neoplasms by exploiting a metabolic difference between tumor cells and host cells. Historical Background In 1953 Kidd1 noted that normal guinea-pig serum has antitumor activity, and Broome2 subsequently showed that the active antitumor substance is L-asparaginase, which is present in high concentration in the serum of the guinea pig and its close relatives. Dolowy and his associates3 used purified guinea-pig serum to treat a boy with acute lymphoblastic leukemia and obtained an objective response. The discovery of Escherichia coli L-asparaginase with antitumor activity presented a source of enzyme in sufficient.

Original languageEnglish (US)
Pages (from-to)732-734
Number of pages3
JournalNew England Journal of Medicine
Volume282
Issue number13
DOIs
StatePublished - Mar 26 1970

ASJC Scopus subject areas

  • General Medicine

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