Abstract
L-Asparaginase affords a unique approach to the chemotherapy of malignant neoplasms by exploiting a metabolic difference between tumor cells and host cells. Historical Background In 1953 Kidd1 noted that normal guinea-pig serum has antitumor activity, and Broome2 subsequently showed that the active antitumor substance is L-asparaginase, which is present in high concentration in the serum of the guinea pig and its close relatives. Dolowy and his associates3 used purified guinea-pig serum to treat a boy with acute lymphoblastic leukemia and obtained an objective response. The discovery of Escherichia coli L-asparaginase with antitumor activity presented a source of enzyme in sufficient.
Original language | English (US) |
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Pages (from-to) | 732-734 |
Number of pages | 3 |
Journal | New England Journal of Medicine |
Volume | 282 |
Issue number | 13 |
DOIs | |
State | Published - Mar 26 1970 |
ASJC Scopus subject areas
- General Medicine