@article{3fb2f7af98c14defa8be749110182f08,
title = "L-ASPARAGINASE AND LYMPHOCYTE BLASTOGENESIS",
author = "Fidler, {Isaiah J.} and Montgomery, {Paul C.} and Ellen Ferguson",
note = "Funding Information: It has been reported that L-asparaginase only inhibits phytohsemagglutinin-induced blastogenesis when the enzyme is added to non-committed lymphocytes. Once these cells are induced to a blastogenic transformation, treatment with L-asparaginase brings about little or no inhibition of their immune reactivity. In view of the above report, and our data, one might speculate that the inhibitory effects of L-asparaginase on lymphocyte blastogenesis could be due to interference with the binding of antigen to the surface of the lymphocyte. Apparently once the antigen is bound to the cell, treatment with the enzyme does not reverse this binding. This proposed mechanism of surface alteration by L-asparaginase could account for its immunosuppressive activity. Further in-vivo and in- vitro binding studies are now under way. This work was supported by grants from the U.S. Public Health Service, GRS 5 S01-RR 05337-10-USPHS DE 02623. Departments of Pathology and Microbiology, School of Dental Medicine and Center for Oral Health Research, University of Pennsylvania, Philadelphia, Pa. 19104, U.S.A.",
year = "1971",
month = nov,
day = "13",
doi = "10.1016/S0140-6736(71)90407-7",
language = "English (US)",
volume = "298",
pages = "1091--1092",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "7733",
}