Lack of association between the BIM deletion polymorphism and the risk of lung cancer with and without EGFR mutations

Hiromichi Ebi, Isao Oze, Takayuki Nakagawa, Hidemi Ito, Satoyo Hosono, Fumihiko Matsuda, Meiko Takahashi, Shinji Takeuchi, Yukinori Sakao, Toyoaki Hida, Anthony C. Faber, Hideo Tanaka, Yasushi Yatabe, Tetsuya Mitsudomi, Seiji Yano, Keitaro Matsuo

    Research output: Contribution to journalArticle

    10 Scopus citations

    Abstract

    Introduction: The BIM deletion polymorphism in intron 2 was found in a significant percent of the Asian population. Patients with epidermal growth factor receptor (EGFR) mutant lung cancers harboring this BIM polymorphism have shorter progression free survival and overall response rates to EGFR tyrosine kinase inhibitors. However, the association between the BIM deletion polymorphism and lung cancer risk is unknown. Methods: The BIM deletion polymorphism was screened by polymerase chain reaction in 765 lung cancer cases and 942 healthy individuals. Results: Carriers possessing one allele of the BIM polymorphism were observed in 13.0% of control cases and 12.8% of lung cancer cases, similar to incidence rates reported earlier in healthy individuals. Homozygote for the BIM polymorphism was observed in four of 942 healthy controls and three of 765 lung cancer cases. The frequency of the BIM deletion polymorphism in lung cancer patients was not related to age, sex, smoking history, or family history of lung cancer. The BIM deletion polymorphism was found in 30 of 212 patients with EGFR wild type lung cancers and 16 of 120 patients with EGFR mutant lung cancers. The frequency of the BIM polymorphism is similar between cancers with wild type EGFR and mutated EGFR (p = 0.78). Conclusion: The BIM deletion polymorphism was not associated with lung cancer susceptibility. Furthermore, the BIM polymorphism is not associated with EGFR mutant lung cancer.

    Original languageEnglish (US)
    Pages (from-to)59-66
    Number of pages8
    JournalJournal of Thoracic Oncology
    Volume10
    Issue number1
    DOIs
    StatePublished - Jan 1 2015

    Keywords

    • BIM polymorphism
    • EGFR mutation
    • Lung cancer
    • Susceptibility

    ASJC Scopus subject areas

    • Oncology
    • Pulmonary and Respiratory Medicine

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  • Cite this

    Ebi, H., Oze, I., Nakagawa, T., Ito, H., Hosono, S., Matsuda, F., Takahashi, M., Takeuchi, S., Sakao, Y., Hida, T., Faber, A. C., Tanaka, H., Yatabe, Y., Mitsudomi, T., Yano, S., & Matsuo, K. (2015). Lack of association between the BIM deletion polymorphism and the risk of lung cancer with and without EGFR mutations. Journal of Thoracic Oncology, 10(1), 59-66. https://doi.org/10.1097/JTO.0000000000000371