Lateral cervical lymph node mapping in papillary thyroid carcinoma: A prospective cohort study

Naisi Huang, Ben Ma, Qing Guan, Yunjun Wang, Li Zhou, Wenjun Wei, Zhongwu Lu, Shuwen Yang, Weibo Xu, Jun Xiang, Qinghai Ji, Yu Wang

Research output: Contribution to journalArticle

Abstract

Objective: To explore the value of nanoparticles (CN) in lateral cervical lymph node mapping in papillary thyroid carcinoma using carbon. Methods: Thyroid cancer patients with suspicious lymph node metastasis but without typical signs of metastatic disease fromMarch 2016 to November 2017 in Fudan University Shanghai Cancer Center were prospectively included in the cohort. Neck dissection was performed in all patients (compartments II-V). Suspicious lateral lymph node metastasis was identified using pre-operative ultrasound or computed tomography. CN were used for lymph node mapping during surgery. Results: A total of 70 surgeries were performed in 67 patients, among which 57 were found to have lateral lymph node metastasis (81.4%). The median number of CN-dyed lateral lymph nodes was 6. Compartment IV had the highest number of CN-dyed positive lymph nodes as well as the highest rate of metastasis, followed by compartment III. In compartments III and IV, the incidence of lymph node metastasis was significantly higher in the CN-dyed group than in the CN-undyed group (P<0.001). When the final pathology of neck dissection was set as the gold standard, lateral CN-dyed lymph node biopsy was found to have a sensitivity of 86.0%; its negative predictive value was 61.9% and its overall accuracy was 88.6%. Conclusions: Injection of CN during surgery was a potential method of mapping lateral lymph nodes in papillary thyroid carcinoma. Compartment III- IV CN-dyed lymph node biopsy had a satisfactory sensitivity and thus, served as a reasonable range for lymph node biopsy.

Original languageEnglish (US)
Pages (from-to)1053-1056
Number of pages4
JournalChinese Journal of Clinical Oncology
Volume45
Issue number20
DOIs
StatePublished - Jan 1 2018

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Cohort Studies
Lymph Nodes
Prospective Studies
Neoplasm Metastasis
Neck Dissection
Biopsy
Papillary Thyroid cancer
Thyroid Neoplasms
Nanoparticles
Carbon
Tomography
Pathology
Injections
Incidence

Keywords

  • lateral cervical lymph node
  • lymph node mapping
  • neck dissection
  • papillary thyroid carcinoma
  • sentinel lymph node biopsy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Lateral cervical lymph node mapping in papillary thyroid carcinoma : A prospective cohort study. / Huang, Naisi; Ma, Ben; Guan, Qing; Wang, Yunjun; Zhou, Li; Wei, Wenjun; Lu, Zhongwu; Yang, Shuwen; Xu, Weibo; Xiang, Jun; Ji, Qinghai; Wang, Yu.

In: Chinese Journal of Clinical Oncology, Vol. 45, No. 20, 01.01.2018, p. 1053-1056.

Research output: Contribution to journalArticle

Huang, N, Ma, B, Guan, Q, Wang, Y, Zhou, L, Wei, W, Lu, Z, Yang, S, Xu, W, Xiang, J, Ji, Q & Wang, Y 2018, 'Lateral cervical lymph node mapping in papillary thyroid carcinoma: A prospective cohort study', Chinese Journal of Clinical Oncology, vol. 45, no. 20, pp. 1053-1056. https://doi.org/10.3969/j.issn.1000-8179.2018.20.675
Huang, Naisi ; Ma, Ben ; Guan, Qing ; Wang, Yunjun ; Zhou, Li ; Wei, Wenjun ; Lu, Zhongwu ; Yang, Shuwen ; Xu, Weibo ; Xiang, Jun ; Ji, Qinghai ; Wang, Yu. / Lateral cervical lymph node mapping in papillary thyroid carcinoma : A prospective cohort study. In: Chinese Journal of Clinical Oncology. 2018 ; Vol. 45, No. 20. pp. 1053-1056.
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abstract = "Objective: To explore the value of nanoparticles (CN) in lateral cervical lymph node mapping in papillary thyroid carcinoma using carbon. Methods: Thyroid cancer patients with suspicious lymph node metastasis but without typical signs of metastatic disease fromMarch 2016 to November 2017 in Fudan University Shanghai Cancer Center were prospectively included in the cohort. Neck dissection was performed in all patients (compartments II-V). Suspicious lateral lymph node metastasis was identified using pre-operative ultrasound or computed tomography. CN were used for lymph node mapping during surgery. Results: A total of 70 surgeries were performed in 67 patients, among which 57 were found to have lateral lymph node metastasis (81.4{\%}). The median number of CN-dyed lateral lymph nodes was 6. Compartment IV had the highest number of CN-dyed positive lymph nodes as well as the highest rate of metastasis, followed by compartment III. In compartments III and IV, the incidence of lymph node metastasis was significantly higher in the CN-dyed group than in the CN-undyed group (P<0.001). When the final pathology of neck dissection was set as the gold standard, lateral CN-dyed lymph node biopsy was found to have a sensitivity of 86.0{\%}; its negative predictive value was 61.9{\%} and its overall accuracy was 88.6{\%}. Conclusions: Injection of CN during surgery was a potential method of mapping lateral lymph nodes in papillary thyroid carcinoma. Compartment III- IV CN-dyed lymph node biopsy had a satisfactory sensitivity and thus, served as a reasonable range for lymph node biopsy.",
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T2 - A prospective cohort study

AU - Huang, Naisi

AU - Ma, Ben

AU - Guan, Qing

AU - Wang, Yunjun

AU - Zhou, Li

AU - Wei, Wenjun

AU - Lu, Zhongwu

AU - Yang, Shuwen

AU - Xu, Weibo

AU - Xiang, Jun

AU - Ji, Qinghai

AU - Wang, Yu

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N2 - Objective: To explore the value of nanoparticles (CN) in lateral cervical lymph node mapping in papillary thyroid carcinoma using carbon. Methods: Thyroid cancer patients with suspicious lymph node metastasis but without typical signs of metastatic disease fromMarch 2016 to November 2017 in Fudan University Shanghai Cancer Center were prospectively included in the cohort. Neck dissection was performed in all patients (compartments II-V). Suspicious lateral lymph node metastasis was identified using pre-operative ultrasound or computed tomography. CN were used for lymph node mapping during surgery. Results: A total of 70 surgeries were performed in 67 patients, among which 57 were found to have lateral lymph node metastasis (81.4%). The median number of CN-dyed lateral lymph nodes was 6. Compartment IV had the highest number of CN-dyed positive lymph nodes as well as the highest rate of metastasis, followed by compartment III. In compartments III and IV, the incidence of lymph node metastasis was significantly higher in the CN-dyed group than in the CN-undyed group (P<0.001). When the final pathology of neck dissection was set as the gold standard, lateral CN-dyed lymph node biopsy was found to have a sensitivity of 86.0%; its negative predictive value was 61.9% and its overall accuracy was 88.6%. Conclusions: Injection of CN during surgery was a potential method of mapping lateral lymph nodes in papillary thyroid carcinoma. Compartment III- IV CN-dyed lymph node biopsy had a satisfactory sensitivity and thus, served as a reasonable range for lymph node biopsy.

AB - Objective: To explore the value of nanoparticles (CN) in lateral cervical lymph node mapping in papillary thyroid carcinoma using carbon. Methods: Thyroid cancer patients with suspicious lymph node metastasis but without typical signs of metastatic disease fromMarch 2016 to November 2017 in Fudan University Shanghai Cancer Center were prospectively included in the cohort. Neck dissection was performed in all patients (compartments II-V). Suspicious lateral lymph node metastasis was identified using pre-operative ultrasound or computed tomography. CN were used for lymph node mapping during surgery. Results: A total of 70 surgeries were performed in 67 patients, among which 57 were found to have lateral lymph node metastasis (81.4%). The median number of CN-dyed lateral lymph nodes was 6. Compartment IV had the highest number of CN-dyed positive lymph nodes as well as the highest rate of metastasis, followed by compartment III. In compartments III and IV, the incidence of lymph node metastasis was significantly higher in the CN-dyed group than in the CN-undyed group (P<0.001). When the final pathology of neck dissection was set as the gold standard, lateral CN-dyed lymph node biopsy was found to have a sensitivity of 86.0%; its negative predictive value was 61.9% and its overall accuracy was 88.6%. Conclusions: Injection of CN during surgery was a potential method of mapping lateral lymph nodes in papillary thyroid carcinoma. Compartment III- IV CN-dyed lymph node biopsy had a satisfactory sensitivity and thus, served as a reasonable range for lymph node biopsy.

KW - lateral cervical lymph node

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KW - sentinel lymph node biopsy

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