Abstract
Li et al. identify a key role of Lats1/2 kinases during intestinal homeostasis for maintaining Wnt pathway activity and intestinal stem cells. Using a selective small-molecule inhibitor of TEAD auto-palmitoylation, they reveal both TEAD-dependent and independent transcriptional regulation downstream of YAP/TAZ in intestinal epithelium.
Original language | English (US) |
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Pages (from-to) | 675-692.e8 |
Journal | Cell Stem Cell |
Volume | 26 |
Issue number | 5 |
DOIs | |
State | Published - May 7 2020 |
Keywords
- Lats1/2
- TEAD
- Wnt
- intestinal stemness
- palmitoylation inhibitor
- tumorigenesis
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Cell Biology