TY - JOUR
T1 - Leukemic involvement in the Thorax
AU - Shroff, Girish S.
AU - Truong, Mylene T.
AU - Carter, Brett W.
AU - Benveniste, Marcelo F.
AU - Kanagal-Shamanna, Rashmi
AU - Rauch, Greg
AU - Viswanathan, Chitra
AU - Boddu, Prajwal C.
AU - Daver, Naval
AU - Wu, Carol C.
N1 - Publisher Copyright:
© RSNA, 2019.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Leukemias are malignancies in which abnormal white blood cells are produced in the bone marrow, resulting in compromise of normal bone marrow hematopoiesis and subsequent cytopenias. Leukemias are classified as myeloid or lymphoid depending on the type of abnormal cells produced and as acute or chronic according to cellular maturity. The four major types of leukemia are acute myeloid leukemia, chronic myeloid leukemia, acute lymphoblastic leukemia, and chronic lymphocytic leukemia. Clinical manifestations are due to either bone marrow suppression (anemia, thrombo-cytopenia, or neutropenia) or leukemic organ infiltration. Imaging manifestations of leukemia in the thorax are myriad.While lymphadenopathy is the most common manifestation of intrathoracic leukemia, leukemia may also involve the lungs, pleura, heart, and bones and soft tissues. Myeloid sarcomas occur in 5%–7% of patients with acute myeloid leukemia and represent masses of myeloid blast cells in an extramedullary location.
AB - Leukemias are malignancies in which abnormal white blood cells are produced in the bone marrow, resulting in compromise of normal bone marrow hematopoiesis and subsequent cytopenias. Leukemias are classified as myeloid or lymphoid depending on the type of abnormal cells produced and as acute or chronic according to cellular maturity. The four major types of leukemia are acute myeloid leukemia, chronic myeloid leukemia, acute lymphoblastic leukemia, and chronic lymphocytic leukemia. Clinical manifestations are due to either bone marrow suppression (anemia, thrombo-cytopenia, or neutropenia) or leukemic organ infiltration. Imaging manifestations of leukemia in the thorax are myriad.While lymphadenopathy is the most common manifestation of intrathoracic leukemia, leukemia may also involve the lungs, pleura, heart, and bones and soft tissues. Myeloid sarcomas occur in 5%–7% of patients with acute myeloid leukemia and represent masses of myeloid blast cells in an extramedullary location.
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U2 - 10.1148/rg.2019180069
DO - 10.1148/rg.2019180069
M3 - Article
C2 - 30620703
AN - SCOPUS:85059796629
SN - 0271-5333
VL - 39
SP - 44
EP - 61
JO - Radiographics
JF - Radiographics
IS - 1
ER -