Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk

Claudia Dalke, Frauke Neff, Savneet Kaur Bains, Scott Bright, Deborah Lord, Peter Reitmeir, Ute Rößler, Daniel Samaga, Kristian Unger, Herbert Braselmann, Florian Wagner, Matthias Greiter, Maria Gomolka, Sabine Hornhardt, Sarah Kunze, Stefan J. Kempf, Lillian Garrett, Sabine M. Hölter, Wolfgang Wurst, Michael RosemannOmid Azimzadeh, Soile Tapio, Michaela Aubele, Fabian Theis, Christoph Hoeschen, Predrag Slijepcevic, Munira Kadhim, Michael Atkinson, Horst Zitzelsberger, Ulrike Kulka, Jochen Graw

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 weeks of age, determined lens opacities for up to 2 years and compared it with overall survival, cytogenetic alterations and cancer development. The highest dose was significantly associated with increased body weight and reduced survival rate. Chromosomal aberrations in bone marrow cells showed a dose-dependent increase 12 months after irradiation. Pathological screening indicated a dose-dependent risk for several types of tumors. Scheimpflug imaging of the lens revealed a significant dose-dependent effect of 1% of lens opacity. Comparison of different biological end points demonstrated long-term effects of low-dose irradiation for several biological end points.

Original languageEnglish (US)
Pages (from-to)99-113
Number of pages15
JournalRadiation and Environmental Biophysics
Volume57
Issue number2
DOIs
StatePublished - May 1 2018

Keywords

  • Low-dose radiation
  • Mouse
  • Radiation-induced cataract
  • Scheimpflug analysis

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • General Environmental Science

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