Abstract
The ubiquitin proteasome pathway is critical in restraining the activities of the p53 tumor suppressor. Numerous E3 and E4 ligases regulate p53 levels. Additionally, deubquitinating enzymes that modify p53 directly or indirectly also impact p53 function. When alterations of these proteins result in increased p53 activity, cells arrest in the cell cycle, senesce, or apoptose. On the other hand, alterations that result in decreased p53 levels yield tumor-prone phenotypes. This review focuses on the physiological relevance of these important regulators of p53 and their therapeutic implications.
Original language | English (US) |
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Pages (from-to) | 1739-1751 |
Number of pages | 13 |
Journal | Genes and Development |
Volume | 28 |
Issue number | 16 |
DOIs | |
State | Published - Aug 15 2014 |
Keywords
- Mdm2
- Mouse models
- Ubiquitination
- p53 regulation
ASJC Scopus subject areas
- Genetics
- Developmental Biology