Liposomes and local hyperthermia: Selective delivery of methotrexate to heated tumors

J. N. Weinstein; R. L. Magin; M. B. Yatvin; D. S. Zaharko

doi:10.1126/science.432641

Liposomes and local hyperthermia: Selective delivery of methotrexate to heated tumors

J. N. Weinstein, R. L. Magin, M. B. Yatvin, D. S. Zaharko

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Abstract

Liposomes with phase transitions a few degrees above physiological temperature delivered more than four times as much methotrexate to in urine tumors heated to 42°C as to unheated control tumors. Most of the accumulated drug appeared to be intracellular and bound to dihydrofolate reductase, the enzyme blocked by methotrexate in its role as an antineoplastic agent.

Original language	English (US)
Pages (from-to)	188-191
Number of pages	4
Journal	Science
Volume	204
Issue number	4389
DOIs	https://doi.org/10.1126/science.432641
State	Published - 1979
Externally published	Yes

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title = "Liposomes and local hyperthermia: Selective delivery of methotrexate to heated tumors",

abstract = "Liposomes with phase transitions a few degrees above physiological temperature delivered more than four times as much methotrexate to in urine tumors heated to 42°C as to unheated control tumors. Most of the accumulated drug appeared to be intracellular and bound to dihydrofolate reductase, the enzyme blocked by methotrexate in its role as an antineoplastic agent.",

author = "Weinstein, {J. N.} and Magin, {R. L.} and Yatvin, {M. B.} and Zaharko, {D. S.}",

year = "1979",

doi = "10.1126/science.432641",

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T2 - Selective delivery of methotrexate to heated tumors

AU - Weinstein, J. N.

AU - Magin, R. L.

AU - Yatvin, M. B.

AU - Zaharko, D. S.

PY - 1979

Y1 - 1979

N2 - Liposomes with phase transitions a few degrees above physiological temperature delivered more than four times as much methotrexate to in urine tumors heated to 42°C as to unheated control tumors. Most of the accumulated drug appeared to be intracellular and bound to dihydrofolate reductase, the enzyme blocked by methotrexate in its role as an antineoplastic agent.

AB - Liposomes with phase transitions a few degrees above physiological temperature delivered more than four times as much methotrexate to in urine tumors heated to 42°C as to unheated control tumors. Most of the accumulated drug appeared to be intracellular and bound to dihydrofolate reductase, the enzyme blocked by methotrexate in its role as an antineoplastic agent.

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Liposomes and local hyperthermia: Selective delivery of methotrexate to heated tumors

Abstract

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