Abstract
The effect of radiation at various doses on the growth of infective, stage-3 larvae (L3) of Litomosoides carinii and on the protection conferred by the attenuated larvae against filarial infection was studied in albino rats. At 20- and 30-kR doses the larvae developed into adults in retarded and sterile forms. No such development was seen when the larvae were irradiated at 40-kR dose and these parasites lived in the host for 25 days. While the 20- and 30-kR-irradiated L3 failed to protect the animal against the infection, a high degree of protection was observed when the rats were immunized with 40-kR-irradiated larvae. The immunized animals showed the presence of serum-dependent cellular adhesion to microfilariae and infective larvae. Preliminary results suggested that microfilariae irradiated at 40 kR do not undergo development in the vector but could immunize the animals against that stage.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 39-44 |
| Number of pages | 6 |
| Journal | Experimental Parasitology |
| Volume | 43 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 1977 |
Keywords
- Albino rats
- Antibody-dependent cell adhesion
- Bdellonyssus bacoti
- Filaria
- Humoral response
- Immunization
- Infective
- Irradiated larvae
- Litomosoides carinii
- Mite
- Nematode
- stage-3 larvae
ASJC Scopus subject areas
- Parasitology
- Immunology
- Infectious Diseases