Abstract
Inflammatory breast cancer (IBC) is a diagnosis based on a constellation of clinical features including a rapid onset of breast erythema and edema (peau d’orange) of a third or more of the skin of the breast and with a palpable border to the edema. Incidence has increased although it makes up only 1–4 % of all breast cancer diagnoses. In spite of some encouraging recent clinical outcome data, published local-regional control rates are consistently lower than expected in non-IBC and are of particular concern in this disease that readily progresses locally to carcinoma en cuirasse. With a focus on radiotherapy, this review provides a critical evaluation of the recent literature evaluating local-regional treatment of IBC, highlights new findings in the local-regional management of IBC, and offers an introduction to future directions regarding the optimal treatment and management of IBC.
Original language | English (US) |
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Pages (from-to) | 37-42 |
Number of pages | 6 |
Journal | Current Breast Cancer Reports |
Volume | 7 |
Issue number | 1 |
DOIs | |
State | Published - Mar 28 2015 |
Keywords
- Breast cancer
- DNA repair
- Immunotherapy
- Inflammatory breast cancer
- Metastatic disease
- Mevalonic acid
- Modified radical mastectomy
- PARP inhibitor
- Post-mastectomy
- Radiation therapy
- Radiosensitizer
- Recurrence
- Statin
- Stem cells
ASJC Scopus subject areas
- Oncology