TY - JOUR
T1 - Localized cutaneous argyria
T2 - Review of a rare clinical mimicker of melanocytic lesions
AU - Gill, Pavandeep
AU - Richards, Kristen
AU - Cho, Woo Cheal
AU - Nagarajan, Priyadharsini
AU - Aung, Phyu P.
AU - Ivan, Doina
AU - Curry, Jonathan L.
AU - Prieto, Victor G.
AU - Torres-Cabala, Carlos A.
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/10
Y1 - 2021/10
N2 - Localized cutaneous argyria is a rare cutaneous disorder that has been associated with occupational exposure, dental procedures, topical agents, acupuncture, earrings, and nasal piercings. In this paper, we review the current literature on localized cutaneous argyria, highlight its clinical and histologic diagnostic features, and then discuss the clinical and histological differential diagnoses for blue-gray skin and black dermal pigment, respectively. We also discuss the utility of ancillary techniques, such as deeper histologic levels, special stains, darkfield microscopy, and advanced micro-analytical techniques in helping diagnose localized cutaneous argyria. Furthermore, we emphasize that a thorough clinical history and astute clinico-pathologic correlation can be the most important diagnostic techniques in correctly diagnosing this rare disorder. Our review aims serve as a reminder to clinicians and pathologists of the importance of including localized cutaneous argyria in the clinical and histological differential diagnosis of pigmented lesions.
AB - Localized cutaneous argyria is a rare cutaneous disorder that has been associated with occupational exposure, dental procedures, topical agents, acupuncture, earrings, and nasal piercings. In this paper, we review the current literature on localized cutaneous argyria, highlight its clinical and histologic diagnostic features, and then discuss the clinical and histological differential diagnoses for blue-gray skin and black dermal pigment, respectively. We also discuss the utility of ancillary techniques, such as deeper histologic levels, special stains, darkfield microscopy, and advanced micro-analytical techniques in helping diagnose localized cutaneous argyria. Furthermore, we emphasize that a thorough clinical history and astute clinico-pathologic correlation can be the most important diagnostic techniques in correctly diagnosing this rare disorder. Our review aims serve as a reminder to clinicians and pathologists of the importance of including localized cutaneous argyria in the clinical and histological differential diagnosis of pigmented lesions.
KW - Argyria
KW - Localized
KW - Melanocytic lesions
KW - Mimickers
KW - Pigment
KW - Silver
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U2 - 10.1016/j.anndiagpath.2021.151776
DO - 10.1016/j.anndiagpath.2021.151776
M3 - Review article
C2 - 34214703
AN - SCOPUS:85109501803
SN - 1092-9134
VL - 54
JO - Annals of Diagnostic Pathology
JF - Annals of Diagnostic Pathology
M1 - 151776
ER -