Long non-coding RNA HOTAIR in carcinogenesis and metastasis

Jinsong Zhang; Peijing Zhang; Li Wang; Hai Long Piao; Li Ma

doi:10.1093/abbs/gmt117

Long non-coding RNA HOTAIR in carcinogenesis and metastasis

Jinsong Zhang, Peijing Zhang, Li Wang, Hai Long Piao, Li Ma

Experimental Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

155 Scopus citations

Abstract

Long non-coding RNAs (lncRNAs) have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA (HOTAIR), a lncRNA located in the HOXC locus, has been shown to repress HOXD gene expression and promote breast cancer metastasis. Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 (PRC2) and regulates chromosome occupancy by EZH2 (a subunit of PRC2), which leads to histone H3 lysine 27 trimethylation of the HOXD locus. Moreover, HOTAIR is pervasively overexpressed in most human cancers compared with noncancerous adjacent tissues. This review summarizes the studies on the HOTAIR lncRNA over the past 6 years.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Acta biochimica et biophysica Sinica
Volume	46
Issue number	1
DOIs	https://doi.org/10.1093/abbs/gmt117
State	Published - Jan 2014

Keywords

HOTAIR
cancer
carcinogenesis
lncRNA
metastasis

ASJC Scopus subject areas

Biophysics
Biochemistry

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10.1093/abbs/gmt117

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title = "Long non-coding RNA HOTAIR in carcinogenesis and metastasis",

abstract = "Long non-coding RNAs (lncRNAs) have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA (HOTAIR), a lncRNA located in the HOXC locus, has been shown to repress HOXD gene expression and promote breast cancer metastasis. Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 (PRC2) and regulates chromosome occupancy by EZH2 (a subunit of PRC2), which leads to histone H3 lysine 27 trimethylation of the HOXD locus. Moreover, HOTAIR is pervasively overexpressed in most human cancers compared with noncancerous adjacent tissues. This review summarizes the studies on the HOTAIR lncRNA over the past 6 years.",

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doi = "10.1093/abbs/gmt117",

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AU - Zhang, Jinsong

AU - Zhang, Peijing

AU - Wang, Li

AU - Piao, Hai Long

AU - Ma, Li

PY - 2014/1

Y1 - 2014/1

N2 - Long non-coding RNAs (lncRNAs) have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA (HOTAIR), a lncRNA located in the HOXC locus, has been shown to repress HOXD gene expression and promote breast cancer metastasis. Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 (PRC2) and regulates chromosome occupancy by EZH2 (a subunit of PRC2), which leads to histone H3 lysine 27 trimethylation of the HOXD locus. Moreover, HOTAIR is pervasively overexpressed in most human cancers compared with noncancerous adjacent tissues. This review summarizes the studies on the HOTAIR lncRNA over the past 6 years.

AB - Long non-coding RNAs (lncRNAs) have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA (HOTAIR), a lncRNA located in the HOXC locus, has been shown to repress HOXD gene expression and promote breast cancer metastasis. Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 (PRC2) and regulates chromosome occupancy by EZH2 (a subunit of PRC2), which leads to histone H3 lysine 27 trimethylation of the HOXD locus. Moreover, HOTAIR is pervasively overexpressed in most human cancers compared with noncancerous adjacent tissues. This review summarizes the studies on the HOTAIR lncRNA over the past 6 years.

KW - HOTAIR

KW - cancer

KW - carcinogenesis

KW - lncRNA

KW - metastasis

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Long non-coding RNA HOTAIR in carcinogenesis and metastasis

Abstract

Keywords

ASJC Scopus subject areas

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