TY - JOUR
T1 - Long non-coding RNAs in ovarian cancer
T2 - expression profile and functional spectrum
AU - Oncul, Selin
AU - Amero, Paola
AU - Rodriguez-Aguayo, Cristian
AU - Calin, George A.
AU - Sood, Anil K.
AU - Lopez-Berestein, Gabriel
N1 - Funding Information:
Selin Oncul was supported by the 2219-Research Grant as part of the International Postdoctoral Research Scholarship Program of Scientific and Technological Research Council of Turkey (TUBITAK). Cristian Rodriguez-Aguayo was supported by the NIH through the Ovarian SPORE Career Enhancement Program and NCI grant P50 CA217685. This work was supported, in part, by the NCI grants (U01 CA213759, P50 CA217685, P50 CA098258, and R35 CA209904), the American Cancer Society Research Professor Award, Judy’s Mission, and the Frank McGraw Memorial Chair in Cancer Research. This review was critically read and edited by a scientific editor in the Department of Scientific Publications at The University of Texas MD Anderson Cancer Center.
Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Long non-coding RNAs (lncRNAs), initially recognized as byproducts of the transcription process, have been proven to play crucial modulatory roles in preserving overall homoeostasis of cells and tissues. Furthermore, aberrant levels of these transcripts have been shown to contribute many diseases, including cancer. Among these, many aspects of ovarian cancer biology have been found to be regulated by lncRNAs, including cancer initiation, progression and dissemination. In this review, we summarize recent studies to highlight the various roles of lncRNAs in ovary in normal and pathological conditions, immune system, diagnosis, prognosis, and therapy. We address lncRNAs that have been extensively studied in ovarian cancer and their contribution to cellular dynamics.
AB - Long non-coding RNAs (lncRNAs), initially recognized as byproducts of the transcription process, have been proven to play crucial modulatory roles in preserving overall homoeostasis of cells and tissues. Furthermore, aberrant levels of these transcripts have been shown to contribute many diseases, including cancer. Among these, many aspects of ovarian cancer biology have been found to be regulated by lncRNAs, including cancer initiation, progression and dissemination. In this review, we summarize recent studies to highlight the various roles of lncRNAs in ovary in normal and pathological conditions, immune system, diagnosis, prognosis, and therapy. We address lncRNAs that have been extensively studied in ovarian cancer and their contribution to cellular dynamics.
KW - Long non-coding RNA
KW - biomarker
KW - diagnosis
KW - oncogene
KW - ovarian cancer
KW - therapeutics
KW - tumour suppressor
UR - http://www.scopus.com/inward/record.url?scp=85076914532&partnerID=8YFLogxK
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U2 - 10.1080/15476286.2019.1702283
DO - 10.1080/15476286.2019.1702283
M3 - Review article
C2 - 31847695
AN - SCOPUS:85076914532
SN - 1547-6286
VL - 17
SP - 1523
EP - 1534
JO - RNA Biology
JF - RNA Biology
IS - 11
ER -