TY - JOUR
T1 - Long noncoding RNA loss in immune suppression in cancer
AU - Hu, Qingsong
AU - Egranov, Sergey D.
AU - Lin, Chunru
AU - Yang, Liuqing
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/9
Y1 - 2020/9
N2 - Long noncoding RNAs (lncRNAs) have multiple functions in the regulation of cellular homeostasis. In recent years, numerous studies have shown that tumor-associated lncRNAs play key roles in promoting and maintaining tumor initiation and progression by shaping the tumor microenvironment through changing tumor cell intrinsic properties. Here, we focus on the roles of lncRNAs in cancer immunology. In the first part, we provide an overview of the roles played by lncRNAs and their deregulation in cancer at the cancer cell- and tumor microenvironment-associated immune cell levels. We go on to describe preclinical strategies for targeting lncRNAs, particularly highlighting the effects on tumor microenvironments. We then discuss the possibility of combining lncRNA targeting and tumor immune checkpoint inhibitor antibodies to treat cancer.
AB - Long noncoding RNAs (lncRNAs) have multiple functions in the regulation of cellular homeostasis. In recent years, numerous studies have shown that tumor-associated lncRNAs play key roles in promoting and maintaining tumor initiation and progression by shaping the tumor microenvironment through changing tumor cell intrinsic properties. Here, we focus on the roles of lncRNAs in cancer immunology. In the first part, we provide an overview of the roles played by lncRNAs and their deregulation in cancer at the cancer cell- and tumor microenvironment-associated immune cell levels. We go on to describe preclinical strategies for targeting lncRNAs, particularly highlighting the effects on tumor microenvironments. We then discuss the possibility of combining lncRNA targeting and tumor immune checkpoint inhibitor antibodies to treat cancer.
KW - Cancer immunotherapy
KW - Long noncoding RNA
KW - Tumor-cell-extrinsic factors
KW - Tumor-cell-intrinsic factors
UR - http://www.scopus.com/inward/record.url?scp=85085877643&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85085877643&partnerID=8YFLogxK
U2 - 10.1016/j.pharmthera.2020.107591
DO - 10.1016/j.pharmthera.2020.107591
M3 - Review article
C2 - 32473960
AN - SCOPUS:85085877643
SN - 0163-7258
VL - 213
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
M1 - 107591
ER -