TY - JOUR
T1 - Long noncoding RNAs in prostate cancer
T2 - mechanisms and applications
AU - Li, Chunlai
AU - Yang, Liuqing
AU - Lin, Chunru
N1 - Publisher Copyright:
© 2014, © 2014 Taylor & Francis Group, LLC.
PY - 2014/9/15
Y1 - 2014/9/15
N2 - A large proportion of the control of gene expression in humans is mediated by noncoding elements in the genome. Long noncoding RNAs (lncRNAs) have emerged as a new class of pivotal regulatory components, orchestrating extensive cellular processes and connections. LncRNAs play various roles from chromatin modification to alternative splicing and post-transcriptional processing and are involved in almost all aspects of eukaryotic regulation. LncRNA-based mechanisms modulate cell fates during development, and their dysregulation underscores many human disorders, especially cancer, through chromosomal translocation, deletion, and nucleotide expansions. Recent studies demonstrate that multiple prostate cancer risk loci are associated with lncRNAs and that ectopic expression of these transcripts triggers a cascade of cellular events driving tumor initiation and progression. The recent increased rate of discovery of lncRNAs has been leveraged for application in clinical strategies such as novel biomarkers and therapeutic targets. Despite this potential, many issues remain to be addressed in this fast-growing field.
AB - A large proportion of the control of gene expression in humans is mediated by noncoding elements in the genome. Long noncoding RNAs (lncRNAs) have emerged as a new class of pivotal regulatory components, orchestrating extensive cellular processes and connections. LncRNAs play various roles from chromatin modification to alternative splicing and post-transcriptional processing and are involved in almost all aspects of eukaryotic regulation. LncRNA-based mechanisms modulate cell fates during development, and their dysregulation underscores many human disorders, especially cancer, through chromosomal translocation, deletion, and nucleotide expansions. Recent studies demonstrate that multiple prostate cancer risk loci are associated with lncRNAs and that ectopic expression of these transcripts triggers a cascade of cellular events driving tumor initiation and progression. The recent increased rate of discovery of lncRNAs has been leveraged for application in clinical strategies such as novel biomarkers and therapeutic targets. Despite this potential, many issues remain to be addressed in this fast-growing field.
KW - biomarker
KW - epigenetic modification
KW - long noncoding RNAs (lncRNAs)
KW - metastasis
KW - prostate cancer
KW - regulatory mechanism
KW - therapeutic target
UR - http://www.scopus.com/inward/record.url?scp=84986191445&partnerID=8YFLogxK
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U2 - 10.4161/23723548.2014.963469
DO - 10.4161/23723548.2014.963469
M3 - Article
C2 - 27308347
AN - SCOPUS:84986191445
SN - 2372-3556
VL - 1
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
IS - 3
M1 - e963469
ER -