TY - JOUR
T1 - Long-term survival in patients with metastatic gastric and gastroesophageal cancer treated with surgery
AU - Badgwell, Brian
AU - Roy-Chowdhuri, Sinchita
AU - Chiang, Yi Ju
AU - Matamoros, Aurelio
AU - Blum, Mariela
AU - Fournier, Keith
AU - Mansfield, Paul
AU - Ajani, Jaffer
N1 - Publisher Copyright:
© 2015 Wiley Periodicals, Inc.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Background The purpose of this study was to determine the survival of patients with metastatic gastric cancer treated with surgery. Methods We reviewed the medical records of 7,404 patients with gastric or gastroesophageal cancer seen from January 1995 to August 2012 at MD Anderson Cancer Center and identified patients with stage IV disease treated with surgery. Kaplan-Meier curves were created to compare overall survival (OS) between groups. Results Of the 82 patients who met inclusion criteria, sites of metastatic disease included peritoneum (N=34, 42%), positive cytology only (N=17, 21%), distant lymph nodes (N=12, 15%), and distant organs (N=19, 23%). The median time from initial cancer diagnosis to surgery for metastatic disease was 10 months (range, 0-70). Surgery included exploratory surgery only (N=16, 20%), primary tumor resection with or without resection of distant disease (N=50, 61%), and distant disease resection only (N=16, 20%). Median follow-up for living patients was 3 years (range, 0.1-14). Median survival for all patients was 1.5 years (range, 0.1-14). Five year OS for patients with peritoneal metastases, positive cytology only, distant lymph nodes, and distant organ involvement was 13, 42, 20, and 34%, respectively. Conclusions Surgery in the setting of metastatic disease is an uncommon clinical scenario and has a considerable risk of exploration without resection, although long-term survival is possible.
AB - Background The purpose of this study was to determine the survival of patients with metastatic gastric cancer treated with surgery. Methods We reviewed the medical records of 7,404 patients with gastric or gastroesophageal cancer seen from January 1995 to August 2012 at MD Anderson Cancer Center and identified patients with stage IV disease treated with surgery. Kaplan-Meier curves were created to compare overall survival (OS) between groups. Results Of the 82 patients who met inclusion criteria, sites of metastatic disease included peritoneum (N=34, 42%), positive cytology only (N=17, 21%), distant lymph nodes (N=12, 15%), and distant organs (N=19, 23%). The median time from initial cancer diagnosis to surgery for metastatic disease was 10 months (range, 0-70). Surgery included exploratory surgery only (N=16, 20%), primary tumor resection with or without resection of distant disease (N=50, 61%), and distant disease resection only (N=16, 20%). Median follow-up for living patients was 3 years (range, 0.1-14). Median survival for all patients was 1.5 years (range, 0.1-14). Five year OS for patients with peritoneal metastases, positive cytology only, distant lymph nodes, and distant organ involvement was 13, 42, 20, and 34%, respectively. Conclusions Surgery in the setting of metastatic disease is an uncommon clinical scenario and has a considerable risk of exploration without resection, although long-term survival is possible.
KW - gastric cancer
KW - gastroesophageal
KW - metastatic
KW - stage IV
KW - surgery
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U2 - 10.1002/jso.23907
DO - 10.1002/jso.23907
M3 - Article
C2 - 25872485
AN - SCOPUS:84928826849
SN - 0022-4790
VL - 111
SP - 875
EP - 881
JO - Journal of surgical oncology
JF - Journal of surgical oncology
IS - 7
ER -